The mTOR pathway integrates a diverse set of environmental cues, such as growth factor
signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half …

Target of rapamycin (TOR) is an evolutionarily conserved protein kinase that controls
multiple cellular processes upon various intracellular and extracellular stimuli. Since its first …

Cell size is an important adaptive trait that influences nearly all aspects of cellular
physiology. Despite extensive characterization of the cell-cycle regulatory network, the …

Cells survey their environment and need to balance growth and anabolism with stress
programmes and catabolism towards maximum cellular bioenergetics economy and …

The TOR kinase is a major regulator of growth in eukaryotes. Many components of the TOR
pathway are implicated in cancer and metabolic diseases in humans. Analysis of the …

General autophagy is an evolutionarily conserved process in eukaryotes, by which
intracellular materials are transported into and degraded inside lysosomes or vacuoles, with …

Cell size is amenable by genetic and environmental factors. The highly conserved nutrient-
responsive Target of Rapamycin (TOR) signaling pathway regulates cellular metabolic …

Target of rapamycin complex 1 (TORC1), a serine/threonine-protein kinase complex highly
conserved among eukaryotes, coordinates cellular growth and metabolism with …

AMPK and TOR protein kinases are the major control points of energy signaling in
eukaryotic cells and organisms. They form the core of a complex regulatory network to co …

The Target of Rapamycin (TOR), a protein kinase, is the central node of a highly conserved
signaling network that regulates cell growth in response to nutrients, hormones, and …