CYP2E1 and oxidative liver injury by alcohol
Y Lu, AI Cederbaum - Free Radical Biology and Medicine, 2008 - Elsevier
Ethanol-induced oxidative stress seems to play a major role in mechanisms by which
ethanol causes liver injury. Many pathways have been suggested to contribute to the ability …
ethanol causes liver injury. Many pathways have been suggested to contribute to the ability …
Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis
AV Ivanov, VT Valuev-Elliston, DA Tyurina… - …, 2016 - pmc.ncbi.nlm.nih.gov
Virally induced liver cancer usually evolves over long periods of time in the context of a
strongly oxidative microenvironment, characterized by chronic liver inflammation and …
strongly oxidative microenvironment, characterized by chronic liver inflammation and …
Identification of hepatoprotective flavonolignans from silymarin
Silymarin, also known as milk thistle extract, inhibits hepatitis C virus (HCV) infection and
also displays antioxidant, anti-inflammatory, and immunomodulatory actions that contribute …
also displays antioxidant, anti-inflammatory, and immunomodulatory actions that contribute …
Hepatitis C virus core protein inhibits mitochondrial electron transport and increases reactive oxygen species (ROS) production
M Korenaga, T Wang, Y Li, LA Showalter… - Journal of Biological …, 2005 - ASBMB
Hepatitis C infection causes a state of chronic oxidative stress, which may contribute to
fibrosis and carcinogenesis in the liver. Previous studies have shown that expression of the …
fibrosis and carcinogenesis in the liver. Previous studies have shown that expression of the …
HCV and oxidative stress in the liver
Hepatitis C virus (HCV) is the etiological agent accounting for chronic liver disease in
approximately 2–3% of the population worldwide. HCV infection often leads to liver fibrosis …
approximately 2–3% of the population worldwide. HCV infection often leads to liver fibrosis …
Inhibition of T-cell inflammatory cytokines, hepatocyte NF-κB signaling, and HCV infection by standardized silymarin
SJ Polyak, C Morishima, MC Shuhart, CC Wang, Y Liu… - Gastroenterology, 2007 - Elsevier
Background & Aims: Chronic hepatitis C is a serious global medical problem necessitating
effective treatment. Because standard of care with pegylated interferon plus ribavirin therapy …
effective treatment. Because standard of care with pegylated interferon plus ribavirin therapy …
Reciprocal effects of micro-RNA-122 on expression of heme oxygenase-1 and hepatitis C virus genes in human hepatocytes
Y Shan, J Zheng, RW Lambrecht, HL Bonkovsky - Gastroenterology, 2007 - Elsevier
Background & Aims: Heme oxygenase-1 (HO-1) is an antioxidant defense and key
cytoprotective enzyme, which is repressed by Bach1. Micro-RNA-122 (miR-122) is …
cytoprotective enzyme, which is repressed by Bach1. Micro-RNA-122 (miR-122) is …
[PDF][PDF] Heme oxygenase‐1 suppresses hepatitis C virus replication and increases resistance of hepatocytes to oxidant injury
Oxidative injury to hepatocytes occurs as a result of hepatitis C virus (HCV) infection and
replication. Modulation of host cell antioxidant enzymes such as heme oxygenase‐1 (HO‐1) …
replication. Modulation of host cell antioxidant enzymes such as heme oxygenase‐1 (HO‐1) …
Hepatitis C virus‐core and non structural proteins lead to different effects on cellular antioxidant defenses
Chronic hepatitis C virus (HCV) infection leads to increased oxidative stress in the liver.
Hepatic antioxidant enzymes provide an important line of defense against oxidative injury …
Hepatic antioxidant enzymes provide an important line of defense against oxidative injury …
Hepatitis C virus core protein, cytochrome P450 2E1, and alcohol produce combined mitochondrial injury and cytotoxicity in hepatoma cells
Background & Aims: Alcohol consumption exacerbates liver injury in chronic hepatitis C, and
enhanced mitochondrial oxidative stress is one possible mechanism. The aim of this study …
enhanced mitochondrial oxidative stress is one possible mechanism. The aim of this study …