The Cyclin-dependent kinase (CDK) class of serine/threonine kinases has crucial roles in
the regulation of cell cycle transition and is mainly involved in the pathogenesis of cancers …

A pyrazole nucleus is an easy-to-prepare scaffold with large therapeutic potential.
Consequently, the search for new pyrazole-based compounds is of great interest to the …

Abstract Treatment options for the management of breast cancer are still inadequate. This
inadequacy is attributed to the lack of effective targeted medications, often resulting in the …

Vascular endothelial growth factor receptor-2 is a dynamic target for therapeutic intervention
in various types of cancer. This study was aimed at exploring the VEGFR-2 inhibitory activity …

A number of azo pyrazole derivatives and novel Schiff bases derived from azo diamino
pyrazole were synthesized. These included 4-(2-arylhydrazono)-4H-pyrazole-3, 5-diamines …

Cancer is considered one of the most lethal diseases responsible for causing deaths
worldwide. Although there have been many breakthroughs in anticancer development …

Chemoselective arylation of 5-aminopyrazoles was performed through oxidative formation of
orthoquinones from catechols catalyzed by Myceliophthora thermophila laccase (Novozym …

Vascular endothelial growth factor receptor-2 is a vital target for therapeutic mediation in
various types of cancer. This study was aimed at exploring the cytotoxic activity of seventeen …

New prodrugs of sulfacetamide as azo compounds were synthesized and have been
evidenced through elemental and spectral analyses. Their synthesis were carried out by …

Background Alzheimer's disease (AD) is a progressive and irreversible neurological
disorder that gradually deteriorates an individual's ability to carry out even the simplest …