Oxidative stress is an increase in the reduction potential or a large decrease in the reducing
capacity of the cellular redox couples. A particularly destructive aspect of oxidative stress is …

Classifying kinases based entirely on small molecule selectivity data is a new approach to
drug discovery that allows scientists to understand relationships between targets. This …

Abstract Ingenol 3-angelate (I3A) is one of the active ingredients in Euphorbia peplus, which
has been used in traditional medicine. Here, we report the initial characterization of I3A as a …

Phorbol esters, the archetypical (PKC) activators, induce apoptosis in androgen-sensitive
LNCaP prostate cancer cells. In this study we evaluate the effect of a novel class of PKC …

The W191G cavity of cytochrome c peroxidase is useful as a model system for introducing
small molecule oxidation in an artificially created cavity. A set of small, cyclic, organic cations …

The central role of protein kinase C (PK-C) in cellular signal transduction has established it
as an important therapeutic target for cancer and other diseases. We have developed a …

The diacylglycerol-responsive C1 domains of protein kinase C and of the related classes of
signaling proteins represent highly attractive targets for drug development. The signaling …

To design strategies to purge latent reservoirs of human immunodeficiency virus type 1 (HIV-
1), we investigated mechanisms by which a non-tumor-promoting phorbol ester, prostratin …

Protein kinase C (PKC) is a widely studied molecular target for the treatment of cancer and
other diseases. We have approached the issue of modifying PKC function by targeting the …

Nur77 orphan steroid receptor and its family member Nor‐1 are required for apoptosis of
developing T cells. In thymocytes, signals from the TCR complex induce Nur77 and Nor‐1 …