▪ Abstract Nerve growth factor (NGF) was discovered 50 years ago as a molecule that
promoted the survival and differentiation of sensory and sympathetic neurons. Its roles in …

Our brain serves as a center for cognitive function and neurons within the brain relay and
store information about our surroundings and experiences. Modulation of this complex …

We have studied the role of phosphatidylinositol 3-OH kinase (PI3K)-Akt signaling in
transforming growth factor β (TGFβ)-mediated epithelial to mesenchymal transition (EMT). In …

Insulin plays a key role in regulating a wide range of cellular processes. However, until
recently little was known about the signalling pathways that are involved in linking the …

Abstract Docosahexanoic acid (22: 6n‐3; DHA) deficiency during development is associated
with impairment in learning and memory, suggesting an important role of DHA in neuronal …

The Cre recombinase mediates precise site-specific recombination between a pair of loxP
sequences through an intermediate containing Holiday junction. The recombination junction …

Background—The intracellular signaling pathways that control cardiomyocyte apoptosis
have not been fully defined. Because insulin-like growth factor-1 (IGF-1) prevents …

Abstract Constitutive phosphatidylinositol 3-kinase (PI3K)-AKT activation has a causal role
in adult T-cell leukaemia-lymphoma (ATLL) and other cancers. ATLL cells do not harbour …

The regulation of neuronal differentiation and neurite outgrowth is essential during
development of the nervous system and is crucial in developing therapies to promote axon …

Mutations of phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a protein
and lipid phosphatase, have been associated with gliomas, macrocephaly, and mental …