Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number
of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating …

Aneuploidy has been recognized as a hallmark of tumorigenesis for more than 100 years,
but the connection between chromosomal errors and malignant growth has remained …

Alzheimer's disease (AD) is the most prevalent form of dementia and is characterized by
abnormal extracellular aggregates of amyloid-β and intraneuronal hyperphosphorylated tau …

Selective targeting of aneuploid cells is an attractive strategy for cancer treatment. However,
it is unclear whether aneuploidy generates any clinically relevant vulnerabilities in cancer …

Diploid and stable karyotypes are associated with health and fitness in animals. By contrast,
whole-genome duplications—doublings of the entire complement of chromosomes—are …

Single-cell analysis is a rapidly evolving approach to characterize genome-scale molecular
information at the individual cell level. Development of single-cell technologies and …

Recent advances in cellular profiling have demonstrated substantial heterogeneity in the
behaviour of cells once deemed'identical', challenging fundamental notions of …

Microscopy image analysis is a major bottleneck in quantification of single-cell microscopy
data, typically requiring human oversight and curation, which limit both accuracy and …

Mitosis is a delicate event that must be executed with high fidelity to ensure genomic
stability. Recent work has provided insight into how mitotic errors shape cancer genomes by …

Aneuploidy, a genomic alternation characterized by deviations in the copy number of
chromosomes, affects organisms from early development through to aging. Although it is a …