The unique structure of G4. 0 PAMAM dendrimers allows a drug to be enclosed in internal
spaces or immobilized on the surface. In the conducted research, the conditions for the …

Currently, the nanoparticle functionalization effect on supramolecular peptide-based
hydrogels remains undescribed, but is expected to affect the hydrogels' self-assembly and …

The chemical design of smart nanocarriers, providing in one nanoformulation combined
anticancer therapies, still remains a challenge in the field of nanomedicine. Among …

Hypothesis The anticancer drug doxorubicin hydrochloride (DX) shows a high solubility in
aqueous media thanks to the positive charge in the ammonium group. This feature …

The experimental absorption measurements in the interval 350–600 nm (Vis), molecular
dynamics simulations, quantum-mechanics calculations and an advanced molecular …

It is widely accepted that solubility–pH profiles of ionizable compounds follow the
Henderson–Hasselbalch equation. However, several studies point out that compounds often …

Although doxorubicin (DOX) is one of the most used chemotherapeutic drugs due to its
efficacy against a wide group of cancer types, it presents severe side effects. As such …

Intermolecular interactions of drug molecules can lead to aggregation, which has a
significant impact on their application. This problem might escape the attention when …

Titanium dioxide (TiO2) nanotubes are attractive materials for drug-delivery systems
because of their biocompatibility, chemical stability, and simple preparation. In this study, we …

Cell membranes constitute the first barrier for the drugs on their way to the cell. Therefore,
their penetration determines the effectivity of the treatment and is defined by the drug-lipid …