Non-alcoholic fatty liver disease: pathophysiological concepts and treatment options

C Grander, F Grabherr, H Tilg - Cardiovascular Research, 2023 - academic.oup.com
The prevalence of non-alcoholic fatty liver disease (NAFLD) is continually increasing due to
the global obesity epidemic. NAFLD comprises a systemic metabolic disease accompanied …

Antisense oligonucleotides: a novel Frontier in pharmacological strategy

D Collotta, I Bertocchi, E Chiapello… - Frontiers in …, 2023 - frontiersin.org
Antisense oligonucleotides (ASOs) are short single stranded synthetic RNA or DNA
molecules, whereas double-stranded RNA nucleotide sequences are called small …

[HTML][HTML] Silencing of STE20-type kinase TAOK1 confers protection against hepatocellular lipotoxicity through metabolic rewiring

Y Xia, E Andersson, SK Anand, E Cansby… - Hepatology …, 2023 - journals.lww.com
Background: NAFLD has become the leading cause of chronic liver disease worldwide
afflicting about one quarter of the adult population. NASH is a severe subtype of NAFLD …

Silencing of STE20‐type kinase MST3 in mice with antisense oligonucleotide treatment ameliorates diet‐induced nonalcoholic fatty liver disease

M Caputo, Y Kurhe, S Kumari, E Cansby… - The FASEB …, 2021 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is emerging as a leading cause of chronic liver
disease worldwide. Despite intensive nonclinical and clinical research in this field, no …

Mechanisms coupling lipid droplets to MASLD pathophysiology

MV Reid, G Fredickson, DG Mashek - Hepatology, 2024 - journals.lww.com
Hepatic steatosis, the buildup of neutral lipids in lipid droplets (LDs), is commonly referred to
as metabolic dysfunction-associated steatotic liver disease (MASLD) when alcohol or viral …

STE20‐type kinases MST3 and MST4 promote the progression of hepatocellular carcinoma: Evidence from human cell culture and expression profiling of liver …

M Caputo, Y Xia, SK Anand, E Cansby… - The FASEB …, 2023 - Wiley Online Library
Hepatocellular carcinoma (HCC) is one of the most fatal and fastest growing malignancies.
Recently, nonalcoholic steatohepatitis (NASH), characterized by liver steatosis …

Inhibition of MAP4K4 signaling initiates metabolic reprogramming to protect hepatocytes from lipotoxic damage

SK Anand, M Caputo, Y Xia, E Andersson… - Journal of Lipid …, 2022 - ASBMB
The primary hepatic consequence of obesity is non-alcoholic fatty liver disease (NAFLD),
affecting about 25% of the global adult population. Non-alcoholic steatohepatitis (NASH) is a …

Lipid droplet-associated kinase STK25 regulates peroxisomal activity and metabolic stress response in steatotic liver [S]

A Nerstedt, Y Kurhe, E Cansby, M Caputo, L Gao… - Journal of lipid …, 2020 - ASBMB
Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are
emerging as leading causes of liver disease worldwide and have been recognized as one of …

[HTML][HTML] Depletion of protein kinase STK25 ameliorates renal lipotoxicity and protects against diabetic kidney disease

E Cansby, M Caputo, L Gao, NM Kulkarni, A Nerstedt… - JCI insight, 2020 - ncbi.nlm.nih.gov
Diabetic kidney disease (DKD) is the most common cause of severe renal disease
worldwide and the single strongest predictor of mortality in diabetes patients. Kidney …

Stk24 protects against obesity-associated metabolic disorders by disrupting the NLRP3 inflammasome

Q Qin, M Li, M Gu, Z Meng, P Xu, H Meng, X Wang - Cell Reports, 2021 - cell.com
Adipose tissue macrophages (ATMs) regulate the occurrence of obesity and its related
diseases. Here, we found that serine/threonine protein kinase 24 (Stk24) expression is …