Antisense oligonucleotides (ASOs) are short single stranded synthetic RNA or DNA molecules, whereas double-stranded RNA nucleotide sequences are called small …
Y Xia, E Andersson, SK Anand, E Cansby… - Hepatology …, 2023 - journals.lww.com
Background: NAFLD has become the leading cause of chronic liver disease worldwide afflicting about one quarter of the adult population. NASH is a severe subtype of NAFLD …
M Caputo, Y Kurhe, S Kumari, E Cansby… - The FASEB …, 2021 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is emerging as a leading cause of chronic liver disease worldwide. Despite intensive nonclinical and clinical research in this field, no …
Hepatic steatosis, the buildup of neutral lipids in lipid droplets (LDs), is commonly referred to as metabolic dysfunction-associated steatotic liver disease (MASLD) when alcohol or viral …
M Caputo, Y Xia, SK Anand, E Cansby… - The FASEB …, 2023 - Wiley Online Library
Hepatocellular carcinoma (HCC) is one of the most fatal and fastest growing malignancies. Recently, nonalcoholic steatohepatitis (NASH), characterized by liver steatosis …
SK Anand, M Caputo, Y Xia, E Andersson… - Journal of Lipid …, 2022 - ASBMB
The primary hepatic consequence of obesity is non-alcoholic fatty liver disease (NAFLD), affecting about 25% of the global adult population. Non-alcoholic steatohepatitis (NASH) is a …
A Nerstedt, Y Kurhe, E Cansby, M Caputo, L Gao… - Journal of lipid …, 2020 - ASBMB
Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are emerging as leading causes of liver disease worldwide and have been recognized as one of …
E Cansby, M Caputo, L Gao, NM Kulkarni, A Nerstedt… - JCI insight, 2020 - ncbi.nlm.nih.gov
Diabetic kidney disease (DKD) is the most common cause of severe renal disease worldwide and the single strongest predictor of mortality in diabetes patients. Kidney …
Q Qin, M Li, M Gu, Z Meng, P Xu, H Meng, X Wang - Cell Reports, 2021 - cell.com
Adipose tissue macrophages (ATMs) regulate the occurrence of obesity and its related diseases. Here, we found that serine/threonine protein kinase 24 (Stk24) expression is …