TLRs in mycobacterial pathogenesis: Black and white or shades of gray

P Mehta, A Ray, S Mazumder - Current Microbiology, 2021 - Springer
Toll-like receptors (TLRs) play critical role in the innate recognition of pathogens besides
orchestrating innate and adaptive immune responses. These receptors exhibit exquisite …

Single-nucleotide variants in the AIM2–absent in melanoma 2 gene (rs1103577) associated with protection for tuberculosis

MBA Figueira, DS de Lima, AL Boechat… - Frontiers in …, 2021 - frontiersin.org
Tuberculosis (TB) remains a serious public health burden worldwide. TB is an infectious
disease caused by the Mycobacterium tuberculosis Complex. Innate immune response is …

An evolutionary recent IFN/IL-6/CEBP axis is linked to monocyte expansion and tuberculosis severity in humans

M Delgobo, DAGB Mendes, E Kozlova, EL Rocha… - elife, 2019 - elifesciences.org
Monocyte counts are increased during human tuberculosis (TB) but it has not been
determined whether Mycobacterium tuberculosis (Mtb) directly regulates myeloid …

Polymorphisms in TLR4 and TNFA and Risk of Mycobacterium tuberculosis Infection and Development of Active Disease in Contacts of Tuberculosis Cases in Brazil …

JM Cubillos-Angulo, MB Arriaga… - Clinical Infectious …, 2019 - academic.oup.com
Background The role of genetic polymorphisms in latent tuberculosis (TB) infection and
progression to active TB is not fully understood. Methods We tested the single-nucleotide …

Synergistic effect of genetic polymorphisms in TLR6 and TLR10 genes on the risk of pulmonary tuberculosis in a Moldavian population

A Varzari, IV Deyneko, E Tudor, H Grallert… - Innate …, 2021 - journals.sagepub.com
Polymorphisms in genes that control immune function and regulation may influence
susceptibility to pulmonary tuberculosis (TB). In this study, 14 polymorphisms in 12 key …

Protective Association of TLR6 rs5743810 with Pulmonary Tuberculosis in the Population of JAMMU Region

S Sharma, I Sharma, S Gupta, R Gupta… - Indian Journal of …, 2025 - Springer
Tuberculosis (TB) is an international public health problem that results in preventable deaths
each year. About 10% of those infected develop tuberculosis, indicating that host defense …

宿主基因与结核病易感性研究概览

HU Wenjuan, XU Kaijin - Journal of Zhejiang University …, 2023 - pmc.ncbi.nlm.nih.gov
“吕贝克灾难”, 双胞胎研究及收养研究等流行病学观察性研究结果都充分表明,
宿主基因是决定机体对结核分枝杆菌是否易感和感染后是否发病的重要因素 …

The association between CCR5, NLRC4, and AIM2 gene polymorphisms and susceptibility to tuberculosis in the Iraqi population.

B KHALEEL, HRS AL-ALWANI… - Biodiversitas: Journal of …, 2024 - search.ebscohost.com
Abstract Khaleel B, Al-Alwani HRS, Asmar A. 2024. The association between CCR5,
NLRC4, and AIM2 gene polymorphisms and susceptibility to tuberculosis in the Iraqi …

Combination of genetic polymorphisms in TLR influence cytokine profile in HCV patients treated with DAAs in the State of Amazonas

AM Tarrago, PV da Silva Neto, R Ramasawmy… - Cytokine, 2020 - Elsevier
Hepatitis C is a public health problem and affects approximately 3% of the world's
population. HCV infections have a wide spectrum of clinical manifestations, and several …

Research progress on genetic control of host susceptibility to tuberculosis.

W Hu, K Xu - Zhejiang da xue xue bao. Yi xue ban= Journal of …, 2023 - europepmc.org
Abstract “吕贝克灾难”, 双胞胎研究及收养研究等流行病学观察性研究结果都充分表明,
宿主基因是决定机体对结核分枝杆菌是否易感和感染后是否发病的重要因素 …