Cancer is driven by multiple types of genetic alterations, which range in size from point
mutations to whole-chromosome gains and losses, known as aneuploidy. Chromosome …

Both embryonic and adult stem cells are endowed with a superior capacity to prevent the
accumulation of genetic lesions, repair them, or avoid their propagation to daughter cells …

Filamentous actin (F-actin) provides cells with mechanical support and promotes the mobility
of intracellular structures. Although F-actin is traditionally considered to be cytoplasmic, here …

Aneuploidy, chromosome stoichiometry that deviates from exact multiples of the haploid
compliment of an organism, exists in eukaryotic microbes, several normal human tissues …

Mesenchymal stem/stromal cells (MSC) show widespread application for a variety of clinical
conditions; therefore, their use necessitates continuous monitoring of their safety. The risk …

Rare hereditary disorders provide unequivocal evidence of the importance of genes in
human disease pathogenesis. Familial syndromes that predispose to osteosarcomagenesis …

The immune system plays a major role in the protection against cancer. Identifying and
characterizing the pathways mediating this immune surveillance are thus critical for …

Chromosome instability (CIN) is the most common form of genome instability and is a
hallmark of cancer. CIN invariably leads to aneuploidy, a state of karyotype imbalance. Here …

In the 20 years since human embryonic stem cells, and subsequently induced pluripotent
stem cells, were first described, it has become apparent that during long-term culture these …

Aneuploidy is a hallmark of human cancer, yet the molecular mechanisms to cope with
aneuploidy-induced cellular stresses remain largely unknown. Here, we induce …