Abstract Calcium ions (Ca2+) are some of the most versatile signalling molecules, and they
have many physiological functions, prominently including muscle contraction, neuronal …

Obesity is a growing health problem worldwide. It is associated with an increased
cardiovascular risk on the one hand of obesity itself and on the other hand of associated …

Despite significant advances in the treatment of myocardial ischemia-reperfusion (I/R) injury,
coronary circulation is a so far neglected target of cardioprotection. In this study, we …

Despite advances in cardioprotection, new therapeutic strategies capable of preventing
ischemia-reperfusion injury of patients are still needed. Here, we discover that sarcoplasmic …

Ryanodine receptors (RyRs) are ubiquitous intracellular calcium (Ca 2+) release channels
required for the function of many organs including heart and skeletal muscle, synaptic …

Single-cell RNA sequencing is a powerful tool by which to characterize the transcriptional
profile of low-abundance cell types, but its application to the inner ear has been hampered …

Intracellular calcium signaling is a universal language source shared by the most part of
biological entities inside cells that, all together, give rise to physiological and functional …

Mitochondrial autophagy (or mitophagy) regulates the mitochondrial network and function to
contribute to multiple cellular processes. The protective effect of homeostatic mitophagy in …

Endothelial cells lining the microvasculature are particularly vulnerable to the deleterious
effects of cardiac ischemia/reperfusion (I/R) injury, a susceptibility that is partially mediated …

Ischemic heart diseases (IHD) are the leading cause of death worldwide. Although the
principal form of treatment of IHD is myocardial reperfusion, the recovery of coronary blood …