Immune cells are important in the pathogenesis of acute pancreatitis and determine disease
severity. Results from cytokine-based clinical trials for acute pancreatitis have been …

With the continued failures of both early diagnosis and treatment options for pancreatic
cancer, it is now time to comprehensively evaluate the role of the immune system on the …

Background: Surgical procedures, including primary tumor resection, have been suggested
to suppress immune competence and to promote postoperative infections and cancer …

Background and Aims: We have previously demonstrated that the stage of differentiation of
tumors has profound effect on the function of NK cells, and that stem-like/poorly …

Generation of T lymphocytes with reactivity against cancer is a prerequisite for effective
adoptive cellular therapies. We established a protocol for tumor-infiltrating lymphocytes …

Recent studies have demonstrated that the interaction between the cancer and the stroma,
play a key role in the development of pancreatic cancer. The desmoplasia, which consists of …

Pancreatic cancer is among the three deadliest cancers worldwide with the lowest 5-year
survival of all cancers. Despite all efforts, therapeutic improvements have barely been made …

The combined/synergistic effect of genetic mutation of KRAS in the pancreas and obesity, a
life-style factor on suppression of natural killer (NK) cells at the pre-neoplastic stage of …

Inflammation plays pivotal roles in the development of pancreatic cancer, from initiation,
progression to metastasis. In humans, many known risk factors for pancreatic cancer …

Ovarian cancer patients with persistent (platinum-resistant) or progressive (platinum-
refractory) disease respond poorly to second line chemotherapy and have low survival …