It is well established that microglial form and function are inextricably linked. In recent years,
the traditional view that microglial form ranges between “ramified resting” and “activated …

Despite intense study, the precise origin and cell lineage of microglia, the resident
mononuclear phagocytes of the nervous system, are still a matter for debate. Unlike …

Glioblastoma multiforme is a deadly cancer for which current treatment options are limited.
The ability of glioblastoma tumor cells to infiltrate the surrounding brain parenchyma …

Recent reports have supported the existence of neural stem cells in the adult mammalian
CNS. Important features of such cells are self-renewal and multipotency, ie, they can give …

Significant advances have been made in the understanding of the pathophysiology,
molecular targets and therapies for the treatment of a variety of nervous-system disorders …

Progressive loss of dopaminergic neurons in the substantia nigra pars compacta and their
terminal connections in the striatum are central features in Parkinson's disease (PD) …

Extracellular ATP is a mediator of intercellular communication and a danger signal. Release
of this and other nucleotides modulates microglia responses via P2Y and P2X receptors …

The symptoms of Parkinson's disease (PD) were first described nearly two centuries ago
and its characteristic pathology identified nearly a century ago, yet its pathogenesis is still …

Sustained microglial activation in the central nervous system (CNS) has been extensively
investigated in age‐related neurodegenerative diseases and has been postulated to lead to …

Parkinson's disease (PD) is a progressive neurodegenerative disorder whose etiology is not
understood. This disease occurs both sporadically and through inheritance of single genes …