Our understanding of cancer biology has increased substantially over the past 30 years.
Despite this, and an increasing pharmaceutical company expenditure on research and …

The use of patient-derived primary cell cultures in cancer preclinical assays has increased in
recent years. The management of resected tumor tissue remains complex and a number of …

Abstract Purpose: Gasdermin B (GSDMB) overexpression/amplification occurs in about 60%
of HER2 breast cancers, where it promotes cell migration, resistance to anti-HER2 therapies …

Tumor cells interact with the microenvironment that specifically supports and promotes tumor
development. Key components in the tumor environment have been linked to various …

Adoptive transfer of T cells engineered with a chimeric antigen receptor (CAR) is deemed as
the silver bullet to overcome the barriers of solid tumor treatment; however, the therapeutic …

Abstract Steroid receptor coactivator 1 (SRC-1) interacts with nuclear receptors and other
transcription factors (TFs) to initiate transcriptional networks and regulate downstream genes …

Steroid regulated cancer cells use nuclear receptors and associated regulatory proteins to
orchestrate transcriptional networks to drive disease progression. In primary breast cancer …

Lung cancer is one of the most prevalent, fatal, and highly heterogeneous diseases that,
seriously threaten human health. Lung cancer is primarily caused by the aberrant …

Purpose: Despite the clinical utility of endocrine therapies for estrogen receptor–positive
(ER) breast cancer, up to 40% of patients eventually develop resistance, leading to disease …

Abstract Three-dimensional (3D) models, such as tumor spheroids and organoids, are
increasingly developed by integrating tissue engineering, regenerative medicine, and …