Peroxisome proliferator‐activated receptor‐γ coactivator (PGC)‐1α is a transcriptional
coactivator described as a master regulator of mitochondrial biogenesis and function …

Mitochondria are the powerhouses of the cell and are involved in essential functions of the
cell, including ATP production, intracellular Ca 2+ regulation, reactive oxygen species …

Mitochondria play a key role in maintaining energy homeostasis in metabolic tissues,
including adipose tissues. The two main types of adipose tissues are the white adipose …

Early in the HIV epidemic, lipodystrophy, characterized by subcutaneous fat loss
(lipoatrophy), with or without central fat accumulation (lipohypertrophy), was recognized as a …

A strong grounding in basic histology is essential for all pathologists. However, there had
always been a gap between histology and pathology in which histologic information …

Low mitochondrial number and activity have been suggested as underlying factors in
obesity, type 2 diabetes, and metabolic syndrome. However, the stage at which …

Mitochondria play a key role in energy metabolism in many tissues, including cardiac and
skeletal muscle, brain, liver, and adipose tissue. Three types of adipose depots can be …

Oxidative stress plays a pathological role in the development of various diseases including
diabetes, atherosclerosis, or cancer. Systemic oxidative stress results from an imbalance …

Although mitochondria in brown adipose tissue and their role in non-shivering
thermogenesis have been widely studied, we have only a limited understanding of the …

Background Within cells, there is a narrow concentration threshold that governs whether
reactive oxygen species (ROS) induce toxicity or act as second messengers. Scope of …