Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease

M Hoenigl, A Arastehfar, MC Arendrup… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Fungal infections are on the rise, driven by a growing population at risk and climate change.
Currently available antifungals include only five classes, and their utility and efficacy in …

[HTML][HTML] Nebulised delivery of RNA formulations to the lungs: From aerosol to cytosol

MT Neary, LM Mulder, PS Kowalski… - Journal of Controlled …, 2024 - Elsevier
In the past decade RNA-based therapies such as small interfering RNA (siRNA) and
messenger RNA (mRNA) have emerged as new and ground-breaking therapeutic agents for …

Not all nebulizers are created equal: Considerations in choosing a nebulizer for aerosol delivery during mechanical ventilation

R MacLoughlin, I Martin-Loeches - Expert Review of Respiratory …, 2023 - Taylor & Francis
Introduction Aerosol therapy is commonly prescribed in the mechanically ventilated patient.
Jet nebulizers (JN) and vibrating mesh nebulizers (VMN) are the most common nebulizer …

Evaluation of aerosol drug delivery options during adult mechanical ventilation in the COVID-19 era

PJ Naughton, M Joyce, M Mac Giolla Eain, A O'Sullivan… - Pharmaceutics, 2021 - mdpi.com
Drug delivery devices used for aerosol therapy during mechanical ventilation to ease the
symptoms of respiratory diseases provide beneficial treatment but can also pose challenges …

Nebuliser therapy in critical care: The past, present and future

A Arnott, M Watson, M Sim - Journal of The Intensive Care …, 2024 - journals.sagepub.com
Nebulisers are devices that reduce a body of liquid into a fine aerosol suitable for inhalation.
Utilising the efficiency of pulmonary drug absorption, they offer a safe and powerful modality …

Cellular therapy for the treatment of paediatric respiratory disease

LC Brennan, A O'Sullivan, R MacLoughlin - International Journal of …, 2021 - mdpi.com
Respiratory disease is the leading cause of death in children under the age of 5 years old.
Currently available treatments for paediatric respiratory diseases including …

Evaluation of aerosol therapy during the escalation of care in a model of adult cystic fibrosis

E Fernandez Fernandez, M Joyce, A O'Sullivan… - Antibiotics, 2021 - mdpi.com
Lung disease is the main cause of morbidity and mortality in cystic fibrosis (CF). CF patients
inhale antibiotics regularly as treatment against persistent bacterial infections. The goal of …

An in vitro study of the effects of respiratory circuit setup and parameters on aerosol delivery during mechanical ventilation

L Reilly, M Mac Giolla Eain, S Murphy… - Frontiers in …, 2024 - frontiersin.org
Introduction Aerosol therapy is often prescribed concurrently during invasive mechanical
ventilation (IMV). This study determines the effects of nebuliser position, circuit …

Evaluation of aerosol drug delivery with concurrent low-and high-flow nasal oxygen

B Murphy, MMG Eain, M Joyce, JB Fink… - ERJ open …, 2022 - Eur Respiratory Soc
Question addressed by study Administration of aerosol to patients receiving high-flow nasal
oxygen (HFNO) ranges from concurrent aerosol delivery by mouthpiece to aerosol via …

Electrochemical Discrimination of Salbutamol from Its Excipients in VentolinTM at Nanoporous Gold Microdisc Arrays

LC Nagle, A Wahl, V Ogourstov, I Seymour, F Barry… - Sensors, 2021 - mdpi.com
The emergence of specific drug–device combination products in the inhalable
pharmaceutical industry demands more sophistication of device functionality in the form of …