Re-examination of nepovirus polyprotein cleavage sites highlights the diverse specificities and evolutionary relationships of nepovirus 3C-like proteases

H Sanfaçon - Archives of Virology, 2022 - Springer
Plant-infecting viruses of the genus Nepovirus (subfamily Comovirinae, family Secoviridae,
order Picornavirales) are bipartite positive-strand RNA viruses with each genomic RNA …

Arabidopsis eIF4E1 protects the translational machinery during TuMV infection and restricts virus accumulation

D Zafirov, N Giovinazzo, C Lecampion, B Field… - PLoS …, 2023 - journals.plos.org
Successful subversion of translation initiation factors eIF4E determines the infection success
of potyviruses, the largest group of viruses affecting plants. In the natural variability of many …

P3/P3N-PIPO of PVY interacting with BI-1 inhibits the degradation of NIb by ATG6 to facilitate virus replication in N. benthamiana

Z Qing, S Ahmad, Y Chen, Q Liang, L Zhang… - Frontiers in Plant …, 2023 - frontiersin.org
Introduction Autophagy not only plays an antiviral role but also can be utilized by viruses to
facilitate virus infection. However, the underlying mechanism of potato virus Y (PVY) …

Potyviral Helper-Component Protease: Multifaced Functions and Interactions with Host Proteins

V Hýsková, K Bělonožníková, J Chmelík… - Plants, 2024 - mdpi.com
The best-characterized functional motifs of the potyviral Helper-Component protease (HC-
Pro) responding for aphid transmission, RNA silencing suppression, movement, symptom …

[HTML][HTML] AlphaFold modeling of nepovirus 3C-like proteinases provides new insights into their diverse substrate specificities

H Sanfaçon, T Skern - Virology, 2024 - Elsevier
The majority of picornaviral 3C proteinases (3C pro) cleavage sites possess glutamine at the
P1 position. Plant nepovirus 3C-like proteinases (3CL pro) show however much broader …

The Mechanism of Resistance of EUROPEAN Plum to Plum pox virus Mediated by Hypersensitive Response Is Linked to VIRAL NIa and Its Protease Activity

B Rodamilans, J Hadersdorfer, Z Berki, B García… - Plants, 2023 - mdpi.com
Plum pox virus (PPV) infects Prunus trees across the globe, causing the serious Sharka
disease. Breeding programs in the past 20 years have been successful, generating plum …

New cherry-adapted Plum pox virus phylogroups discovered in Russia

S Chirkov, A Sheveleva, T Gasanova, D Kwon… - Plant …, 2022 - Am Phytopath Society
Plum pox virus (PPV) is the most pathogenic virus of stone fruit crops worldwide. Unusual
PPV isolates were discovered on sour cherry (Prunus cerasus L.) and steppe cherry (P …

Molecular crosstalk between plant translation initiation complexes influences the outcome of virus infection

D Zafirov, N Giovinazzo, C Lecampion, B Field… - bioRxiv, 2023 - biorxiv.org
Successful subversion of translation initiation factors 4E and 4G determines the infection
success of potyviruses, the largest group of viruses affecting plants. In the natural variability …

[HTML][HTML] Identification of viral genes involved in pepper mottle virus replication and symptom development in Nicotiana benthamiana

M Fang, J Yu, HR Kwak, KH Kim - Frontiers in Plant Science, 2022 - frontiersin.org
Pepper mottle virus (PepMoV) infects primarily Capsicum species, including pepper and bell
pepper which are important vegetable and spice crops in Korea. We have previously …

Viral protease NIa-Pro increases MEDIATOR SUBUNIT16 cleavage and plant susceptibility to turnip mosaic virus and its aphid vector Myzus persicae

S Ray, T Murad, GD Arena, K Arshad, Z Arendsee… - bioRxiv, 2023 - biorxiv.org
Plant viruses, such turnip mosaic virus (TuMV), both trigger and inhibit host plant defense
responses, including defenses that target their insect vectors, such as aphids. TuMV …