Intestinal stem cells at the bottom of crypts fuel the rapid renewal of the different cell types
that constitute a multitasking tissue. The intestinal epithelium facilitates selective uptake of …

Background At the surface of body organs, epithelial tissues must withstand harsh external
environments. To do so, they rely heavily upon stem cells to replenish and repair wounds …

The colorectal adenoma–carcinoma sequence has provided a paradigmatic framework for
understanding the successive somatic genetic changes and consequent clonal expansions …

Intestinal stem cells, characterized by high Lgr5 expression, reside between Paneth cells at
the small intestinal crypt base and divide every day. We have carried out fate mapping of …

We consider some of the problems involved in current discussions on stem cells in adult
mammalian tissues. The present concepts involve a number of pitfalls, weaknesses and …

With the capacity for rapid self-renewal and regeneration, the intestinal epithelium is
stereotypical of stem cell–supported tissues. Yet the pattern of stem cell turnover remains in …

The epithelium of the adult mammalian intestine is in a constant dialog with its underlying
mesenchyme to direct progenitor proliferation, lineage commitment, terminal differentiation …

The epithelial lining of the intestine, stomach, and skin is continuously exposed to
environmental assault, imposing a requirement for regular self-renewal. Resident adult stem …

During embryonic and postnatal development, the different cells types that form adult tissues
must be generated and specified in a precise temporal manner. During adult life, most …

Cell divisions during embryonic development give rise to new differentiated cell types or
increase the total number of cells in the embryo. In contrast, the major role of cell division in …