Dexmedetomidine (DEX) is a highly selective α2 adrenergic receptor (α2AR) agonist
currently used in clinical settings. Because DEX has dose‐dependent advantages of …

Ischaemia/reperfusion injury is an important cause of liver damage during surgical
procedures such as hepatic resection and liver transplantation, and represents the main …

Oxidative stress and apoptosis play a key role in the pathogenesis of sepsis‐associated
acute kidney injury (AKI). Dexmedetomidine (DEX) may present renal protective effects in …

Acute kidney injury (AKI) is a frequent and serious complication of sepsis; however, there
are currently no effective therapies. Inflammation and oxidative stress are the major …

Background/Aims: Dexmedetomidine (Dex), a specific agonist of α2-adrenoceptor, has been
reported to have extensive pharmacological effects. In this study, we focused on the …

Background We compared intestinal, hepatic, and other organ function after hepatic portal
occlusion with or without dexmedetomidine administration under general anaesthesia …

The abnormally high nucleotide-binding oligomerization domain (NOD)-like receptor family
pyrin domain containing 3 (NLRP3) inflammasome activity is a typical characteristic of …

Results: After PSM and adjusting for significant covariates, the multivariate analysis
demonstrated no association between the use of dexmedetomidine and RFS (hazard ratio …

Study objective Dexmedetomidine, a highly selective α 2-receptor agonist, has been widely
used for protection against ischemia-reperfusion (IR) injury. We hypothesized that …

Dexmedetomidine (dex) is a potent, highly selective and specific α2-adrenoreceptor agonist.
This experimental study was designed to investigate protective and therapeutic effect of two …