DNA-RNA hybrids play a physiological role in cellular processes, but often, they represent
non-scheduled co-transcriptional structures with a negative impact on transcription …

The spatiotemporal control of RNA polymerase II (Pol II)-mediated gene transcription is
tightly and intricately regulated. In addition, preservation of the integrity of the DNA template …

Selective inhibitors of PARP1 and PARP2 (PARP1/2) are used to treat cancer patients with
deficiencies in the repair of DNA via homologous recombination. Here we provide a …

Given that genomic DNA exerts its function by being transcribed, it is critical for the
maintenance of homeostasis that DNA damage, such as double-strand breaks (DSBs) …

Abstract Structure-specific endonucleases (SSEs) have key roles in DNA replication,
recombination and repair, and emerging roles in transcription. These enzymes have …

Heart failure has reached epidemic proportions in a progressively ageing population. The
molecular mechanisms underlying heart failure remain elusive, but evidence indicates that …

Cetaceans are a clade of highly specialized aquatic mammals that include the largest
animals that have ever lived. The largest whales can have∼ 1,000× more cells than a …

Tobacco-specific nitrosamines (TSNAs) are emitted during smoking and form indoors by
nitrosation of nicotine. Two of them, N′-nitrosonornicotine (NNN) and 4 …

Ubiquitination has traditionally been viewed in the context of polyubiquitination that is
essential for marking proteins for degradation via the proteasome. Recent discoveries have …

Congenital nucleotide excision repair (NER) deficiency gives rise to several cancer-prone
and/or progeroid disorders. It is not understood how defects in the same DNA repair …