Rational design of immunomodulatory hydrogels for chronic wound healing

M Kharaziha, A Baidya, N Annabi - Advanced Materials, 2021 - Wiley Online Library
With all the advances in tissue engineering for construction of fully functional skin tissue,
complete regeneration of chronic wounds is still challenging. Since immune reaction to the …

Bioadhesive technology platforms

SJ Wu, X Zhao - Chemical Reviews, 2023 - ACS Publications
Bioadhesives have emerged as transformative and versatile tools in healthcare, offering the
ability to attach tissues with ease and minimal damage. These materials present numerous …

Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing

H Atcha, A Jairaman, JR Holt, VS Meli… - Nature …, 2021 - nature.com
Macrophages perform diverse functions within tissues during immune responses to
pathogens and injury, but molecular mechanisms by which physical properties of the tissue …

Macrophage phenotypes in tissue repair and the foreign body response: Implications for biomaterial-based regenerative medicine strategies

KE Martin, AJ García - Acta biomaterialia, 2021 - Elsevier
Macrophages are a highly heterogeneous and plastic population of cells that are crucial for
tissue repair and regeneration. This has made macrophages a particularly attractive target …

Snail-inspired AFG/GelMA hydrogel accelerates diabetic wound healing via inflammatory cytokines suppression and macrophage polarization

Z Zhou, T Deng, M Tao, L Lin, L Sun, X Song, D Gao… - Biomaterials, 2023 - Elsevier
Diabetic foot ulcers (DFUs) are a severe and rapidly growing diabetic complication, but
treating DFUs remains a challenge for the existing therapies are expensive and highly non …

Hydrogel scaffolds for tissue engineering: the importance of polymer choice

CD Spicer - Polymer Chemistry, 2020 - pubs.rsc.org
Hydrogel scaffolds that can repair or regrow damaged biological tissue have great potential
for the treatment of injury and disease. These biomaterials are widely used in the tissue …

Dealing with the foreign‐body response to implanted biomaterials: strategies and applications of new materials

D Zhang, Q Chen, C Shi, M Chen, K Ma… - Advanced Functional …, 2021 - Wiley Online Library
Foreign‐body response caused by implanted biomaterials seriously impedes the function of
implants and is a major obstacle to the development of implantable biomaterials and …

Achieving tissue-level softness on stretchable electronics through a generalizable soft interlayer design

Y Li, N Li, W Liu, A Prominski, S Kang, Y Dai… - Nature …, 2023 - nature.com
Soft and stretchable electronics have emerged as highly promising tools for biomedical
diagnosis and biological studies, as they interface intimately with the human body and other …

Hydrogel crosslinking modulates macrophages, fibroblasts, and their communication, during wound healing

S Butenko, RR Nagalla, CF Guerrero-Juarez… - Nature …, 2024 - nature.com
Biomaterial wound dressings, such as hydrogels, interact with host cells to regulate tissue
repair. This study investigates how crosslinking of gelatin-based hydrogels influences …

Mechanobiology of macrophages: how physical factors coregulate macrophage plasticity and phagocytosis

N Jain, J Moeller, V Vogel - Annual review of biomedical …, 2019 - annualreviews.org
In addition to their early-recognized functions in host defense and the clearance of apoptotic
cell debris, macrophages play vital roles in tissue development, homeostasis, and repair. If …