Colorectal cancer (CRC) is among the most lethal and prevalent malignancies in the world
and was responsible for nearly 881,000 cancer-related deaths in 2018. Surgery and …

Simple Summary Growth factors are hormone-like molecules able to promote division and
migration of normal cells, but cancer captured the underlying mechanisms to unleash tumor …

The ErbB receptor family, also known as the EGF receptor family or type I receptor family,
includes the epidermal growth factor (EGF) receptor (EGFR) or ErbB1/Her1, ErbB2/Her2 …

Podocytes are an integral part of the glomerular filtration barrier, a structure that prevents
filtration of large proteins and macromolecules into the urine. Podocyte function is …

Cell motility is regulated by multiple processes, including cell protrusion, cell retraction, cell–
matrix adhesion, polarized exocytosis and polarized vesicle trafficking, each of which is …

Genetic studies of hereditary forms of nephrotic syndrome have identified several proteins
that are involved in regulating the permselective properties of the glomerular filtration …

Almost all mammalian cell types have morphologies that are uniquely tailored to their
physiological functions. This immense variation in cell shape depends on an underlying …

MicroRNAs (miRNAs) are a class of post-transcriptional gene regulators with critical
functions in normal cellular processes as well as disease processes. They are small …

Heat stress is a common and, therefore, an important environmental impact on cells and
organisms. While much attention has been paid to severe heat stress, moderate temperature …

The genes encoding microRNAs of the human miR-200 family map to fragile chromosomal
regions and are frequently downregulated upon tumor progression. Although having been …