The function of the fibrinolytic system was first identified to dissolve fibrin to maintain
vascular patency. Connections between the fibrinolytic system and many other physiological …

The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results
in the release of vasoactive kinins (bradykinin-related peptides). This complex system …

Cancer dissemination and metastasis is synonymous with invasive cell migration; a process
in which the extracellular matrix (ECM) plays the dual role of the substratum on which the …

Bradykinin is formed by the interaction of factor XII, prekallikrein, and high-molecular-weight
kininogen on negatively charged inorganic surfaces (silicates, urate, and pyrophosphate) or …

Members of the lymphocyte antigen-6 (Ly6)/urokinase-type plasminogen activator receptor
(uPAR) superfamily of proteins are cysteine-rich proteins characterized by a distinct disulfide …

Angiogenesis is the process of sprouting and configuring new blood vessels from pre-
existing blood vessels, whereas the hemostatic system maintains the liquid flow of blood by …

Corresponding aulhor: Klaus T. Preissner, Haemostasis Research Unit, Kerckhoff-Klinik,
MPI, Sprudelhof 11, D-61231 Bad Nauheim, Germany; Tel+ 49-6032-996-719; Fax+ 49 …

The plasma bradykinin-forming cascade and the complement pathways share many
elements, including cross-activation, common control mechanisms, and shared binding …

The urokinase-type plasminogen activator (uPA), its inhibitor PA I-1 and its cellular receptor
(uPAR), play a pivotal role in pericellular proteolysis. In addition, through their interactions …

Our recent investigations have postulated a human umbilical vein endothelial cell (HUVEC)-
associated prekallikrein activator (PKA). When prekallikrein (PK) assembles on high …