[HTML][HTML] Current understanding of nucleoside analogs inhibiting the SARS-CoV-2 RNA-dependent RNA polymerase

T Xu, L Zhang - Computational and Structural Biotechnology Journal, 2023 - Elsevier
Since the outbreak of the COVID-19 pandemic, severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp) has become a main …

Main and papain-like proteases as prospective targets for pharmacological treatment of coronavirus SARS-CoV-2

LV Yevsieieva, KO Lohachova, A Kyrychenko… - RSC …, 2023 - pubs.rsc.org
The pandemic caused by the coronavirus SARS-CoV-2 led to a global crisis in the world
healthcare system. Despite some progress in the creation of antiviral vaccines and mass …

Rapidly identifying new coronavirus mutations of potential concern in the Omicron variant using an unsupervised learning strategy

LP Zhao, TP Lybrand, PB Gilbert, TH Payne, CW Pyo… - Scientific Reports, 2022 - nature.com
Extensive mutations in the Omicron spike protein appear to accelerate the transmission of
SARS-CoV-2, and rapid infections increase the odds that additional mutants will emerge. To …

Peptide inhibitors derived from the nsp7 and nsp8 cofactors of nsp12 targeting different substrate binding sites of nsp12 of the SARS-CoV-2

NR Jena, S Pant - Journal of Biomolecular Structure and Dynamics, 2024 - Taylor & Francis
SARS-COV-2 is responsible for the COVID-19 pandemic, which has infected more than 767
million people worldwide including about 7 million deaths till 5 June 2023. Despite the …

Exploring nucleoside analogs: key targets in the viral life cycle-advancing strategies against SARS-CoV-2

R Garg, R Kumar, R Srivastava… - Medicinal Chemistry …, 2024 - Springer
The COVID-19 pandemic has been a major reason behind the increased research aimed at
the identification of effective antiviral agents. Among these, Nucleoside analogs have shown …

Molecular dynamics simulation study on the binding mechanism between carbon nanotubes and RNA-dependent RNA polymerase

Z Ma, J Xu, C Wang, Z Liu, G Zhu - Journal of Biomolecular …, 2024 - Taylor & Francis
Carbon nanotubes (CNTs) have potential prospects in disease treatment, so it is of great
significance to study CNTs as the possible inhibitors of RNA-dependent RNA polymerase …

[PDF][PDF] Фавипиравир как средство терапии COVID-19

КВ Балакин, РВ Стороженко… - Научный бюллетень …, 2023 - chemrar.ru
Фавипиравир, разработанный японскими исследователями в качестве средства
терапии гриппа и других РНК-вирусных инфекций, в 2020-2022 годах стал массово …

[HTML][HTML] Subtle structural differences of nucleotide analogs may impact SARS-CoV-2 RNA-dependent RNA polymerase and exoribonuclease activity

A Madariaga-Mazón, JJ Naveja, A Becerra… - Computational and …, 2022 - Elsevier
The rapid spread and public health impact of the novel SARS-CoV-2 variants that cause
COVID-19 continue to produce major global impacts and social distress. Several vaccines …

[PDF][PDF] Favipiravir for the treatment of COVID-19

KV Balakin, RV Storozhenko, EV Jakubova - Nauchnyj bjulleten'HimRar, 2023 - chemrar.ru
Favipiravir, developed by Japanese researchers as a treatment for influenza and other RNA
viral infections, in 2020-2022, has become extensively used in Russia, China, India, Turkey …

[引用][C] EFFECTS OF 5′-TRIPHOSPHATE METABOLITES OF SPECIFIC ANTIVIRAL DRUGS ON CTP SYNTHASE ACTIVITY

T Gillis - 2021