[HTML][HTML] Hyaluronic acid: molecular mechanisms and therapeutic trajectory
RC Gupta, R Lall, A Srivastava, A Sinha - Frontiers in veterinary …, 2019 - frontiersin.org
Hyaluronic acid (also known as hyaluronan or hyaluronate) is naturally found in many
tissues and fluids, but more abundantly in articular cartilage and synovial fluid (SF) …
tissues and fluids, but more abundantly in articular cartilage and synovial fluid (SF) …
Absorption, distribution and mechanism of action of SYSADOAS
P du Souich - Pharmacology & therapeutics, 2014 - Elsevier
Abstract Symptomatic Slow Acting Drugs for Osteoarthritis (SYSADOA), such as hyaluronic
acid (HA), chondroitin sulfate (CS) and glucosamine (GlcN) are natural compounds …
acid (HA), chondroitin sulfate (CS) and glucosamine (GlcN) are natural compounds …
The anti-inflammatory and matrix restorative mechanisms of platelet-rich plasma in osteoarthritis
EA Sundman, BJ Cole, V Karas… - … American journal of …, 2014 - journals.sagepub.com
Background: Intra-articular (IA) treatment with platelet-rich plasma (PRP) for osteoarthritis
(OA) results in improved patient-reported pain and function scores. Purpose: To measure the …
(OA) results in improved patient-reported pain and function scores. Purpose: To measure the …
Synergistic anabolic actions of hyaluronic acid and platelet-rich plasma on cartilage regeneration in osteoarthritis therapy
Osteoarthritis (OA) is a common disease associated with tissue inflammation, physical
disability and imbalanced homeostasis in cartilage. For advanced treatments, biological …
disability and imbalanced homeostasis in cartilage. For advanced treatments, biological …
Platelet-rich plasma injection as an effective treatment for temporomandibular joint osteoarthritis
Purpose Emerging evidence has suggested that platelet-rich plasma (PRP) might be of
assistance in the treatment of degenerative conditions of the joints. The aim of the present …
assistance in the treatment of degenerative conditions of the joints. The aim of the present …
Lubricin/proteoglycan 4 binding to CD44 receptor: a mechanism of the suppression of proinflammatory cytokine–induced synoviocyte proliferation by lubricin
A Al‐Sharif, M Jamal, LX Zhang, K Larson… - Arthritis & …, 2015 - Wiley Online Library
Objective To evaluate the binding of recombinant human proteoglycan 4 (rhPRG4) to CD44
receptor and its consequences on cytokine‐induced synoviocyte proliferation. Methods The …
receptor and its consequences on cytokine‐induced synoviocyte proliferation. Methods The …
[HTML][HTML] Reactive oxygen species induce Cox-2 expression via TAK1 activation in synovial fibroblast cells
Y Onodera, T Teramura, T Takehara, K Shigi, K Fukuda - FEBS open bio, 2015 - Elsevier
Oxidative stress within the arthritis joint has been indicated to be involved in generating
mediators for tissue degeneration and inflammation. COX-2 is a mediator in inflammatory …
mediators for tissue degeneration and inflammation. COX-2 is a mediator in inflammatory …
A review on the wide range applications of hyaluronic acid as a promising rejuvenating biomacromolecule in the treatments of bone related diseases
C Li, Z Cao, W Li, R Liu, Y Chen, Y Song, G Liu… - International journal of …, 2020 - Elsevier
Hyaluronic acid (HA) is a multifunctional high molecular weight polysaccharide produced by
synoviocytes, fibroblasts, and chondrocytes, and is naturally found in many tissues and …
synoviocytes, fibroblasts, and chondrocytes, and is naturally found in many tissues and …
The pericellular hyaluronan of articular chondrocytes
W Knudson, S Ishizuka, K Terabe, EB Askew… - Matrix Biology, 2019 - Elsevier
The story of hyaluronan in articular cartilage, pericellular hyaluronan in particular,
essentially is also the story of aggrecan. Without properly tethered aggrecan, the load …
essentially is also the story of aggrecan. Without properly tethered aggrecan, the load …
Hypoxia promotes redifferentiation and suppresses markers of hypertrophy and degeneration in both healthy and osteoarthritic chondrocytes
BD Markway, H Cho, B Johnstone - Arthritis research & therapy, 2013 - Springer
Introduction Hypoxia is considered to be a positive influence on the healthy chondrocyte
phenotype and cartilage matrix formation. However, hypoxia-inducible factors (HIFs) have …
phenotype and cartilage matrix formation. However, hypoxia-inducible factors (HIFs) have …