SUMOylation is a reversible post-translational modification which has emerged as a crucial
molecular regulatory mechanism, involved in the regulation of DNA damage repair, immune …

Post-translational protein modification by small ubiquitin-like modifier (SUMO), termed
sumoylation, is an important mechanism in cellular responses to stress and one that …

Protein conjugation with Small ubiquitin-like modifier (SUMOylation) has critical roles during
cell cycle progression. Many important cell cycle regulators, including many oncogenes and …

Small ubiquitin-like modifier (SUMO) family proteins regulate target-protein functions by post-
translational modification. However, a potent and selective inhibitor targeting the SUMO …

Objective Pancreatic ductal adenocarcinoma (PDAC) has the characteristics of high-density
desmoplastic stroma, a distinctive immunosuppressive microenvironment and is profoundly …

Small ubiquitin-like modifiers (SUMOs) regulate virtually all nuclear processes. The fate of
the target protein is determined by the architecture of the attached SUMO protein, which can …

SUMOylation is a post-translational modification characterized by covalent and reversible
binding of small ubiquitin-like modifier (SUMO) to a target protein. In mammals, four different …

Purpose High levels of heterogeneity and immunosuppression characterize the HCC
immune microenvironment (TME). Unfortunately, the majority of hepatocellular carcinoma …

Serum lactate dehydrogenase (LDH) is a prognostic factor for patients with stage IV
melanoma. To gain insights into the biology underlying this prognostic factor, we analyzed …

Since posttranslational modification (PTM) by the small ubiquitin-related modifiers (SUMOs)
was discovered over a decade ago, a huge number of cellular proteins have been found to …