Continuous cell lines consist of cultured cells derived from a specific donor and tissue of
origin that have acquired the ability to proliferate indefinitely. These cell lines are well …

In vitro human cell line models have been widely used for cancer pharmacogenomic studies
to predict clinical response, to help generate pharmacogenomic hypothesis for further …

To date, over 100 small-molecule oncology drugs have been approved by the FDA.
Because of the inherent heterogeneity of tumors, these small molecules are often …

High-throughput and high-content databases are increasingly important resources in
molecular medicine, systems biology, and pharmacology. However, the information usually …

The NCI-60 cell lines are the most frequently studied human tumor cell lines in cancer
research. This panel has generated the most extensive cancer pharmacology database …

The NCI-60 cell line collection is a very widely used panel for the study of cellular
mechanisms of cancer in general and in vitro drug action in particular. It is a model system …

Purpose: Human cell lines are useful for studying cancer biology and preclinically modeling
cancer therapy, but can be misidentified and cross-contamination is unfortunately common …

OBJECTIVES: Cell lines derived from human ovarian and endometrial cancers, and their
immortalized non-malignant counterparts, are critical tools to investigate and characterize …

Lung cancer cell lines have made a substantial contribution to lung cancer translational
research and biomedical discovery. A systematic approach to initiating and characterizing …

Since the early 1990s the Developmental Therapeutics Program of the National Cancer
Institute (NCI) has utilized a panel of 60 human tumor cell lines (NCI60) representing 9 …