Stability of protein pharmaceuticals: Recent advances

MC Manning, RE Holcomb, RW Payne… - Pharmaceutical …, 2024 - Springer
There have been significant advances in the formulation and stabilization of proteins in the
liquid state over the past years since our previous review. Our mechanistic understanding of …

Microfluidic techniques for mechanical measurements of biological samples

PF Salipante - Biophysics Reviews, 2023 - pubs.aip.org
The use of microfluidics to make mechanical property measurements is increasingly
common. Fabrication of microfluidic devices has enabled various types of flow control and …

New facet in viscometry of charged associating polymer systems in dilute solutions

A Gosteva, AS Gubarev, O Dommes, O Okatova… - Polymers, 2023 - mdpi.com
The peculiarities of viscosity data treatment for two series of polymer systems exhibiting
associative properties: brush-like amphiphilic copolymers—charged alkylated N-methyl-N …

A first insight into the developability of an immunoglobulin G3: a combined computational and experimental approach

GB Armstrong, A Lewis, V Shah, P Taylor… - ACS Pharmacology & …, 2024 - ACS Publications
Immunoglobulin G 3 (IgG3) monoclonal antibodies (mAbs) are high-value scaffolds for
developing novel therapies. Despite their wide-ranging therapeutic potential, IgG3 …

On rheological properties of disc-shaped cellulose nanocrystals

J Li, Z Wang, P Wang, J Tian, T Liu, J Guo, W Zhu… - Carbohydrate …, 2024 - Elsevier
The rheological properties of a substance depend greatly on its morphology, and rod-
shaped cellulose nanocrystals (RCNCs) and cellulose nanofibrils (CNFs) have been …

Nucleation in protein aggregation in biotherapeutic development: a look into the heart of the event

TK Das, DK Chou, W Jiskoot, P Arosio - Journal of Pharmaceutical Sciences, 2022 - Elsevier
In spite of extensive research, protein aggregation still remains one of the most difficult
phenomena to be understood in the field of biologics research and development. Protein …

Application of a simple short-range attraction and long-range repulsion colloidal model toward predicting the viscosity of protein solutions

SS Virk, PT Underhill - Molecular Pharmaceutics, 2022 - ACS Publications
Some hard-sphere colloidal models have been criticized for inaccurately predicting the
solution viscosity of complex biological molecules like proteins. Competing short-range …

Stability of monoclonal antibodies as solid formulation for auto-injectors: a pilot study

F Garcia-Villen, I Gallego, M Sainz-Ramos… - Pharmaceutics, 2023 - mdpi.com
Drug adherence is a significant medical issue, often responsible for sub-optimal outcomes
during the treatment of chronic diseases such as rheumatoid or psoriatic arthritis …

[HTML][HTML] On the relationship between viscoelasticity and water diffusion in soft biological tissues

J Braun, J Bernarding, J Snellings, T Meyer… - Acta Biomaterialia, 2024 - Elsevier
Magnetic resonance elastography (MRE) and diffusion-weighted imaging (DWI) are
complementary imaging techniques that detect disease based on viscoelasticity and water …

Antibody association in solution: cluster distributions and mechanisms

S Brudar, L Breydo, E Chung, KA Dill, N Ehterami… - Mabs, 2024 - Taylor & Francis
Understanding factors that affect the clustering and association of antibodies molecules in
solution is critical to their development as therapeutics. For 19 different monoclonal antibody …