The endothelium, a cellular monolayer lining the blood vessel wall, plays a critical role in
maintaining multiorgan health and homeostasis. Endothelial functions in health include …

Atherosclerotic vascular disease and its complications are among the top causes of mortality
worldwide. In the vascular lumen, atherosclerotic plaques are not randomly distributed …

The ion channels Piezo1 and TRPV4 have both, independently, been implicated in high
venous pressure–and fluid shear stress–induced vascular hyperpermeability in endothelial …

Omega-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid,
docosapentaenoic acid and docosahexaenoic acid, display a wide range of beneficial …

Mechanical stress from blood flow has a significant effect on endothelial physiology, with a
key role in initiating vasoregulatory signals. Disturbances in blood flow, such as in regions of …

Transient Receptor Potential (TRP) channels are a family of ion channels whose members
are distributed among all kinds of animals, from invertebrates to vertebrates. The importance …

Atherosclerosis, the principal cause of cardiovascular death worldwide, is a pathological
disease characterized by fibro-proliferation, chronic inflammation, lipid accumulation, and …

Glycosaminoglycans (GAGs) and proteoglycans (PGs) are essential components of the
extracellular matrix (ECM) with pivotal roles in cellular mechanosensing pathways. GAGs …

Objective Cartilage health is maintained in response to a range of mechanical stimuli
including compressive, shear and tensile strains and associated alterations in osmolality …

Icariin is a major bioactive pharmaceutical constituent isolated from Chinese medicine
Horny Goat Weed (Ying Yang Huo) with potent cardiovascular protective functions …