Molecular mechanisms and physiological changes behind benign tracheal and subglottic stenosis in adults

A Marchioni, R Tonelli, A Andreani… - International Journal of …, 2022 - mdpi.com
Laryngotracheal stenosis (LTS) is a complex and heterogeneous disease whose
pathogenesis remains unclear. LTS is considered to be the result of aberrant wound-healing …

Laryngotracheal stenosis: Mechanistic review

DJ Carpenter, OA Hamdi, AM Finberg… - Head & Neck, 2022 - Wiley Online Library
Background The purpose of this review article is to summarize the existing literature
surrounding wound healing mechanisms in laryngotracheal stenosis. Methods A review of …

[HTML][HTML] Idiopathic subglottic stenosis arises at the epithelial interface of host and pathogen

A Gelbard, MH Shilts, B Strickland, K Motz… - Research …, 2023 - ncbi.nlm.nih.gov
Background Idiopathic subglottic stenosis (iSGS) is a rare fibrotic disease of the proximal
airway affecting adult Caucasian women nearly exclusively. Life-threatening ventilatory …

Impact of adjuvant medical therapies on surgical outcomes in idiopathic subglottic stenosis

MR Hoffman, A Patro, LC Huang, SC Chen… - The …, 2021 - Wiley Online Library
Objectives/Hypothesis Adjuvant medications including proton pump inhibitors (PPI),
antibiotics (trimethoprim/sulfamethoxazole [TMP‐SMX]), and inhaled corticosteroids (ICS) …

Dysfunctional epithelial barrier is characterized by reduced e‐cadherin in idiopathic subglottic stenosis

AJ Berges, R Ospino, L Mafla, S Collins… - The …, 2024 - Wiley Online Library
Objectives To aim of the study was to characterize the molecular profile and functional
phenotype of idiopathic subglottic stenosis (iSGS)‐scar epithelium. Methods Human …

Defining the microbiome of the head and neck: A contemporary review

R Samarrai, S Frank, A Lum, K Woodis… - American Journal of …, 2022 - Elsevier
Objective The purpose of this paper is to define the microbiome of the head and neck by
characterizing and distinguishing the commensal bacteria from pathogenic species. Study …

Vancomycin-loaded polycaprolactone electrospinning nanofibers modulate the airway interfaces to restrain tracheal stenosis

Y Zhao, C Tian, K Wu, X Zhou, K Feng, Z Li… - … in Bioengineering and …, 2021 - frontiersin.org
Site-specific release of therapeutics at the infected trachea remains a great challenge in
clinic. This work aimed to develop a series of vancomycin (VA)-loaded polycaprolactone …

Increased expression of PD‐1 and PD‐L1 in patients with laryngotracheal stenosis

RJ Davis, I Lina, D Ding, EL Engle, J Taube… - The …, 2021 - Wiley Online Library
Objectives Laryngotracheal stenosis (LTS) is a fibrotic condition of the upper airway. Recent
evidence suggests dysregulated host immunity plays a role in LTS development and …

Drug‐Eluting Endotracheal Tubes for Preventing Bacterial Inflammation in Subglottic Stenosis

MR Aronson, S Ali Akbari Ghavimi… - The …, 2022 - Wiley Online Library
Objectives/Hypothesis Subglottic stenosis (SGS) results from dysregulated extracellular
matrix deposition by laryngotracheal fibroblasts causing scar tissue formation following …

Observation of the Gut Microbiota Profile in C57BL/6 Mice Induced by Plasmodium berghei ANKA Infection

W Guan, S Yang, Y Zhao, W Cheng, X Song… - Frontiers in cellular …, 2021 - frontiersin.org
The genus of Plasmodium parasites can cause malaria, which is a prevalent infectious
disease worldwide, especially in tropical and subtropical regions. C57BL/6 mice infected …