Mounting evidence indicates that the lysosome-autophagy pathway plays a critical role in
iron release from ferritin, the main iron storage cellular protein, hence in the distribution of …

Iron accumulation is a recurring pathological phenomenon in many neurological diseases
including Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, and …

Common variants in the iron regulatory protein HFE contribute to systematically increased
iron levels, yet the effects in the brain are not fully characterized. It is commonly believed that …

Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease of the central
nervous system, characterized by progressive loss of motor neurons, and occurring in both …

BACKGROUND: Intracerebral hemorrhage (ICH) is characterized by bleeding into the brain
parenchyma. During an ICH, iron released from the breakdown of hemoglobin creates a …

Background: In recent years, the role of iron metabolism in amyotrophic lateral sclerosis
(ALS) attracts more and more attention, and some studies have focused on the link between …

Background: Data from published studies about the effect of HFE polymorphisms on ALS
risk, phenotype, and survival are still inconclusive. We aimed at evaluating whether the p …

Abstract H63D HFE is associated with iron dyshomeostasis and oxidative stress; each of
which plays an important role in amyotrophic lateral sclerosis (ALS) pathogenesis. To …

Objectives The aim of the study was to detect changes in the levels of ferritin heavy chain
(FHC), ferritin light chain (FLC), and transferrin in the cerebrospinal fluid (CSF) and serum of …

The role of iron dyshomeostasis in neurodegenerative disease has implicated the
involvement of genes that regulate brain iron. The homeostatic iron regulatory gene (HFE) …