Galectins are a family of mammalian carbohydrate-binding proteins expressed by many cell
types. Galectins can function intracellularly and can also be secreted to bind to cell surface …

The vast range and complexity of glycan structures and their dynamic variations in health
and disease have presented formidable challenges toward understanding the biological …

Gene regulatory networks (GRNs) are key determinants of cell function and identity and are
dynamically rewired during development and disease. Despite decades of advancement …

Immune checkpoint inhibitors exhibit limited response rates in patients with triple-negative
breast cancer (TNBC), suggesting that additional immune escape mechanisms may exist …

Abstract The programmed death-1 (PD-1) and the PD ligand 1 (PD-L1) interaction
represents a key immune checkpoint within the tumor microenvironment (TME), and PD-1 …

Background: Currently, no therapies exist for treating and improving outcomes in patients
with severe peripheral artery disease (PAD). MicroRNA93 (miR93) has been shown to …

Systemic sclerosis (SSc) is a complex disease that affects the connective tissue, causing
fibrosis. SSc patients show altered immune cell composition and activation in the peripheral …

BSH-1 is an O-acetylated xylan obtained from bamboo shavings. This study determined the
protective effects of BSH-1 against loperamide (Lop)-induced constipation in mice. Mice …

Galectins, a family of glycan-binding proteins, are well-known for their role in shaping the
immune microenvironment. They can directly affect the activity and survival of different …

Galectin-2 is a prototype member of the galactoside-binding galectin family. It is
predominately expressed in the gastrointestinal tract but is also detected in several other …