Th1 and Th17 cells in tuberculosis: protection, pathology, and biomarkers
IV Lyadova, AV Panteleev - Mediators of inflammation, 2015 - Wiley Online Library
The outcome of Mycobacterium tuberculosis (Mtb) infection ranges from a complete
pathogen clearance through asymptomatic latent infection (LTBI) to active tuberculosis (TB) …
pathogen clearance through asymptomatic latent infection (LTBI) to active tuberculosis (TB) …
Heterogeneity of Human CD4+ T Cells Against Microbes
F Sallusto - Annual review of immunology, 2016 - annualreviews.org
CD4+ T helper (Th) cells play a central role in the adaptive immune response by providing
help to B cells and cytotoxic T cells and by releasing different types of cytokines in tissues to …
help to B cells and cytotoxic T cells and by releasing different types of cytokines in tissues to …
Single-cell eQTL models reveal dynamic T cell state dependence of disease loci
Non-coding genetic variants may cause disease by modulating gene expression. However,
identifying these expression quantitative trait loci (eQTLs) is complicated by differences in …
identifying these expression quantitative trait loci (eQTLs) is complicated by differences in …
[HTML][HTML] Intratumoral CD4+ T cells mediate anti-tumor cytotoxicity in human bladder cancer
Responses to anti-PD-1 immunotherapy occur but are infrequent in bladder cancer. The
specific T cells that mediate tumor rejection are unknown. T cells from human bladder …
specific T cells that mediate tumor rejection are unknown. T cells from human bladder …
Lymphatic migration of unconventional T cells promotes site-specific immunity in distinct lymph nodes
Lymphatic transport of molecules and migration of myeloid cells to lymph nodes (LNs)
continuously inform lymphocytes on changes in drained tissues. Here, using LN …
continuously inform lymphocytes on changes in drained tissues. Here, using LN …
Exhaustion-associated regulatory regions in CD8+ tumor-infiltrating T cells
GP Mognol, R Spreafico, V Wong… - Proceedings of the …, 2017 - National Acad Sciences
T-cell exhaustion is a progressive loss of effector function and memory potential due to
persistent antigen exposure, which occurs in chronic viral infections and cancer. Here we …
persistent antigen exposure, which occurs in chronic viral infections and cancer. Here we …
Precursors of human CD4+ cytotoxic T lymphocytes identified by single-cell transcriptome analysis
CD4+ cytotoxic T lymphocytes (CD4-CTLs) have been reported to play a protective role in
several viral infections. However, little is known in humans about the biology of CD4-CTL …
several viral infections. However, little is known in humans about the biology of CD4-CTL …
Single-cell transcriptomic analysis of allergen-specific T cells in allergy and asthma
CD4+ T helper (TH) cells and regulatory T (Treg) cells that respond to common allergens
play an important role in driving and dampening airway inflammation in patients with …
play an important role in driving and dampening airway inflammation in patients with …
Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease
TJ Scriba, A Penn-Nicholson, S Shankar… - PLoS …, 2017 - journals.plos.org
Our understanding of mechanisms underlying progression from Mycobacterium tuberculosis
infection to pulmonary tuberculosis disease in humans remains limited. To define such …
infection to pulmonary tuberculosis disease in humans remains limited. To define such …
The balance between protective and pathogenic immune responses in the TB-infected lung
IM Orme, RT Robinson, AM Cooper - Nature immunology, 2015 - nature.com
Tuberculosis is a disease of the lung, and efficient transmission is dependent on the
generation of a lesion in the lung, which results in a bacterium-laden cough. Mycobacterium …
generation of a lesion in the lung, which results in a bacterium-laden cough. Mycobacterium …