Synaptic dysfunction is closely related to Alzheimer's disease (AD) which is also recognized
as synaptic disorder. β-amyloid (Aβ) is one of the main pathogenic factors in AD, which …

The roles of the Wnt signalling pathway in several developmental processes, including
synaptic differentiation, are well characterized. The expression of Wnt ligands and Wnt …

Wnts comprise a large family of proteins that have shown to be part of a signaling cascade
that regulates several aspects of development including organogenesis, midbrain …

c-Jun N-terminal kinases (JNKs), first characterized as stress-activated members of the
mitogen-activated protein kinase (MAPK) family, have become a focus of inhibitor screening …

The Wnt signaling pathway plays a role in the development of the central nervous system
and growing evidence indicates that Wnts also regulates the structure and function of the …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive
deterioration of cognitive abilities, accumulation of the amyloid-β-peptide (Aβ) and synaptic …

The formation of synaptic connections requires a dialogue between pre and postsynaptic
cells to coordinate the assembly of the presynaptic release machinery and the postsynaptic …

Although Aβ peptides are causative agents in Alzheimer's disease (AD), the underlying
mechanisms are still elusive. We report that Aβ42 induces a translational block by activating …

The first mammalian Wnt to be discovered, Wnt-1, was found to be essential for the
development of a large part of the mouse brain over 25 years ago. We have since learned …

In the adult brain new neurons are continuously generated mainly in two regions, the
subventricular zone (SVZ) of the lateral ventricles and the subgranular zone (SGZ) in the …