Age-related macular degeneration (AMD) is the leading cause of blindness in the developed
world. It is a complex multifactorial disease, and despite new advances in treatment, many …

Introduction With the recent FDA approvals of pegcetacoplan (SYFOVRE, Apellis
Pharmaceuticals) and avacincaptad pegol (IZERVAY, Astellas Pharmaceuticals) …

Purpose To evaluate the effect of eculizumab, a systemic inhibitor of complement
component (C5), on the growth of geographic atrophy (GA) in patients with age-related …

PURPOSE: To present the current understanding of age-related macular degeneration
(AMD) pathogenesis, based on clinical evidence, epidemiologic data, histopathologic …

Age‐related macular degeneration (AMD) is the most common cause of blindness among
the elderly, especially in Western countries. Although the prevalence, risk factors, and …

This meta-analysis was conducted to determine the genotypic effects of rs4149056 and
rs2306283 polymorphism in SLCO1B1 gene on myopathy in patients with statin. Studies …

Importance Deficient 25-hydroxyvitamin D (25 [OH] D) concentrations have been associated
with increased odds of age-related macular degeneration (AMD). Objective To examine …

Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in folate
metabolism and DNA synthesis. A number of studies have examined the association of …

Genetic variants influencing the transcriptome have been extensively studied. However, the
impact of the genetic factors on the human proteome is largely unexplored, mainly due to …

Purpose.: To investigate the safety and effects of subconjunctival sirolimus, an mTOR
inhibitor and immunosuppressive agent, for the treatment of geographic atrophy (GA) …