SELEX stands for systematic evolution of ligands by exponential enrichment. This method,
described primarily in 1990 [Ellington, AD, Szostak, JW, 1990. In vitro selection of RNA …

Agents able to bind tightly and selectively to disease markers can greatly benefit disease
diagnosis and therapy. Aptamers are functional molecules, usually DNA or RNA …

Nucleic acid ligands, also known as aptamers, are a class of macromolecules that are being
used in several novel nanobiomedical applications. Aptamers are characterized by high …

Aptamers are functional molecules able to bind tightly and selectively to disease markers,
offering great potential for applications in disease diagnosis and therapy. MUC1 is a well …

Nucleic acid aptamers are molecules that bind to their ligands with high affinity and
specificity. Unlike other functional nucleic acids such as antisense oligonucleotides …

The interaction of activated Ras with Raf initiates signaling cascades that contribute to a
significant percentage of human tumors, suggesting that agents that specifically disrupt this …

Antibodies have been the workhorse reagents of protein capture and quantification since
their 1959 debut in the RIA s developed by Yalow and Berson. However, there are technical …

Synthetic nucleic acid ligands, called aptamers, bind to protein targets with high specificity
and affinity. They are very potent inhibitors of protein function and their application can …

Many signalling proteins involved in diverse functions such as cell growth and differentiation
can act as oncogenes and cause cellular transformation. These molecules represent …

Toward the expansion of the genetic alphabet of DNA, several artificial third base pairs
(unnatural base pairs) have been created. Synthetic DNAs containing the unnatural base …