In the last decade, tremendous progress has been made in understanding the biology of
microglia–ie the fascinating immigrated resident immune cell population of the central …

Chondroitin sulfate proteoglycans and heparan sulfate proteoglycans are major constituents
of the extracellular matrix and the cell surface in the brain. Proteoglycans bind with many …

Human pluripotent stem cell-based in vitro models that reflect human physiology have the
potential to reduce the number of drug failures in clinical trials and offer a cost-effective …

Some neuropsychiatric disease, including schizophrenia, may originate during prenatal
development, following periods of gestational hypoxia and placental oxidative stress. Here …

An ongoing challenge in children presenting with motor delay/impairment early in life is to
identify neurogenetic disorders with a clinical phenotype, which can be misdiagnosed as …

Proteoglycans are diverse, complex extracellular/cell surface macromolecules composed of
a central core protein with covalently linked glycosaminoglycan (GAG) chains; both of these …

The morphological alterations of cortical lamination observed in mouse models of
developmental hypothyroidism prompted the recognition that these experimental changes …

The mammalian brain consists of numerous compartments that are closely connected with
each other via neural networks, comprising the basis of higher order brain functions. The …

Inflammation has been implicated in a wide variety of neurological disorders and there is
increasing evidence for long-term consequences of inflammation during early brain …

Exposure to maternal stress (MS) and mutations in GAD1, which encodes the γ-aminobutyric
acid (GABA) synthesizing enzyme glutamate decarboxylase (GAD) 67, are both risk factors …