Discovered more than 30 years ago, the angiotensin AT 2 receptor (AT 2 R) has evolved
from a binding site with unknown function to a firmly established major effector within the …

Swynghedauw, Bernard. Molecular Mechanisms of Myocardial Remodeling. Physiol. Rev.
79: 215–262, 1999.—“Remodeling” implies changes that result in rearrangement of …

The renin-angiotensin system (RAS) is a coordinated hormonal cascade in the control of
cardiovascular, renal, and adrenal function that governs body fluid and electrolyte balance …

Objective: We sought to determine whether angiotensin II (Ang II) promotes hypertrophy of
cardiac myocytes directly or via paracrine mechanisms mediated by cardiac fibroblasts …

Two isoforms of myosin heavy chain (MyHC), alpha and beta, exist in the mammalian
ventricular myocardium, and their relative expression is correlated with the contractile …

Background—The formation of angiotensin-(1-7) from either angiotensin (Ang) I or Ang II in
failing human hearts is not well understood. Methods and Results—Angiotensinase activity …

Since the discovery of nonpeptidic ligands, the receptors for angiotensin (Ang) II have been
classified into 2 subtypes (Ang II type 1 receptor [AT1-R] and Ang II type 2 receptor [AT2-R]) …

Background—Angiotensin II (Ang II) is implicated in cardiac remodeling and is increasingly
recognized for its profibrotic activity. Methods and Results—Because little is known about …

The distributions of angiotensin AT1 and AT2 receptors have been mapped by in vitro
autoradiography throughout most tissues of many mammals, including humans. In addition …

Aims Plasma levels of individual neurohormones (NH) have been proposed as reliable
indicators for risk stratification of patients with heart failure (HF). Mainly because of small …