The mammary gland is a compound, branched tubuloalveolar structure and a major
characteristic of mammals. The mammary gland has evolved from epidermal apocrine …

FGFs (fibroblast growth factors) and their receptors (FGFRs) play essential roles in tightly
regulating cell proliferation, survival, migration and differentiation during development and …

The fibroblast growth factor receptors (FGFR) play essential roles both during development
and in the adult. Upon ligand binding, FGFRs induce intracellular signaling networks that …

The mammary gland is one of the most regenerative organs in the body, with the majority of
development occurring postnatally and in the adult mammal. Formation of the ductal tree is …

The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …

Fibroblast Growth Factor Receptor (FGFR) signalling plays a critical role in breast embryonal
development, tissue homeostasis, tumorigenesis and metastasis. FGFR, its numerous FGF …

Simple Summary The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR)
system represents an emerging therapeutic target in breast cancer. Here, we discussed …

During lung development, parabronchial SMC (PSMC) progenitors in the distal
mesenchyme secrete fibroblast growth factor 10 (Fgf10), which acts on distal epithelial …

The mammary gland undergoes a spectacular series of changes as it develops, and
maintains a remarkable capacity to remodel and regenerate for several decades. Mammary …

FOXA1, estrogen receptor α (ERα) and GATA3 independently predict favorable outcome in
breast cancer patients, and their expression correlates with a differentiated, luminal tumor …