Upon activation, naïve CD4+ T cells differentiate into a number of specialized T helper (Th)
cell subsets. Th2 cells are central players in immunity to helminths and are implicated in …

Metabolic reprogramming is a hallmark of T cell activation and function. As our
understanding of T cell metabolism increases, so does our appreciation of its inherent …

There is close crosstalk between cancer metabolism and immunity. Cancer metabolism
regulation is a promising therapeutic target for cancer immunotherapy. Warburg effect is …

Background Lactic acid produced by tumors has been shown to overcome immune
surveillance, by suppressing the activation and function of T cells in the tumor …

Invariant Natural Killer T (iNKT) cells are a non-conventional, innate-like, T cell population
that recognize lipid antigens presented by the cluster of differentiation (CD) 1d molecule …

Dendritic cell (DC)-based antitumor vaccines have proven to be a safe approach, but often
fail to generate robust results between trials. Translation to the clinic has been hindered in …

Advances made in chimeric antigen receptor (CAR) T cell therapy have revolutionized the
treatment and management of certain cancers. Currently, B cell malignancies have been …

The ex-vivo expansion of antigen-specific T-cells for adoptive T-cell immunotherapy requires
active interaction between T-cells and antigen-presenting cells therefore culture density and …

Körperliche Aktivität und gezielte sporttherapeutische Maßnahmen haben sich mittlerweile
als Supportivtherapie in der Onkologie bewährt, um Nebenwirkungen der Erkrankung und …

General physical activity and physical exercise have become a meaningful supportive
therapy in oncology, since they have proven to reduce several disease-and treatment …