Ammonia production, excretion, toxicity, and defense in fish: a review

YK Ip, SF Chew - Frontiers in physiology, 2010 - frontiersin.org
Many fishes are ammonotelic but some species can detoxify ammonia to glutamine or urea.
Certain fish species can accumulate high levels of ammonia in the brain or defense against …

[PDF][PDF] Osmoregulation and excretion.

EH Larsen, LE Deaton, H Onken, M O'Donnell… - membranes, 2014 - researchgate.net
The article discusses advances in osmoregulation and excretion with emphasis on how
multicellular animals in different osmotic environments regulate their milieu intérieur …

Oxidative stress and antioxidant enzymes in liver and white muscle of Nile tilapia juveniles in chronic ammonia exposure

MM Hegazi, ZI Attia, OA Ashour - Aquatic toxicology, 2010 - Elsevier
Oxidative stress and antioxidant enzyme activities in liver and white muscle of Nile tilapia
(Oreochromis niloticus) juveniles (10±1.2 g) in chronic exposure to sublethal total ammonia …

Regulation of amino acid metabolism as a defensive strategy in the brain of three freshwater teleosts in response to high environmental ammonia exposure

AK Sinha, T Giblen, H AbdElgawad, M De Rop… - Aquatic Toxicology, 2013 - Elsevier
Many teleosts have evolved mechanisms to cope with ammonia toxicity in the brain when
confronted with high environmental ammonia (HEA). In the present study, the possible role …

Temporal correlations of ferroptosis, inflammation and oxidative stress under acute ammonia exposure in brain tissue of yellow catfish (Pelteobagrus fulvidraco)

X Long, K He, M Zhang, M Li, Z Wang, C Wang… - … and Physiology Part C …, 2023 - Elsevier
Ammonia is one of the most serious environmental stressors which severely affect fishery
production. Ammonia toxicity to fish has a tight relationship with oxidative stress …

Induction of four glutamine synthetase genes in brain of rainbow trout in response to elevated environmental ammonia

PA Wright, SL Steele, A Huitema… - Journal of …, 2007 - journals.biologists.com
The key strategy for coping with elevated brain ammonia levels in vertebrates is the
synthesis of glutamine from ammonia and glutamate, catalyzed by glutamine synthetase …

Ammonia as a respiratory gas in water and air-breathing fishes

DJ Randall, YK Ip - Respiratory physiology & neurobiology, 2006 - Elsevier
Ammonia is produced in the liver and excreted as NH3 by diffusion across the gills. Elevated
ammonia results in an increase in gill ventilation, perhaps via stimulation of gill oxygen …

Inhibition of glutamine synthetase during ammonia exposure in rainbow trout indicates a high reserve capacity to prevent brain ammonia toxicity

LA Sanderson, PA Wright… - Journal of …, 2010 - journals.biologists.com
Glutamine synthetase (GSase), the enzyme that catalyses the conversion of glutamate and
ammonia to glutamine, is present at high levels in vertebrate brain tissue and is thought to …

Piscine insights into comparisons of anoxia tolerance, ammonia toxicity, stroke and hepatic encephalopathy

PJ Walsh, CM Veauvy, MD McDonald… - … and Physiology Part A …, 2007 - Elsevier
Although the number of fish species that have been studied for both hypoxia/anoxia
tolerance and ammonia tolerance are few, there appears to be a correlation between the …

Ammonia toxicity and tolerance in the brain of the African sharptooth catfish, Clarias gariepinus

NLJ Wee, YYM Tng, HT Cheng, SML Lee, SF Chew… - Aquatic Toxicology, 2007 - Elsevier
The African sharptooth catfish Clarias gariepinus lives in freshwater, is an obligatory air-
breather, and can survive on land during drought. The objective of this study was to …