Natural withanolides, an update

G Xia, S Cao, L Chen, F Qiu - Natural Product Reports, 2022 - pubs.rsc.org
Covering: March 2010 to December 2020. Previous review: Nat. Prod. Rep., 2011, 28, 705
This review summarizes the latest progress and perspectives on the structural classification …

An overview of biotechnological interventions and abiotic elicitors on biomass and withanolide biosynthesis in Withania somnifera (L.) Dunal

L Sharma, B Maurya, SP Rai - Industrial Crops and Products, 2023 - Elsevier
Withania somnifera is a solanaceous plant species having immense therapeutic potential
and commercial values, attributed by pharmacologically active secondary metabolites viz …

A WRKY transcription factor from Withania somnifera regulates triterpenoid withanolide accumulation and biotic stress tolerance through modulation of phytosterol …

AK Singh, SR Kumar, V Dwivedi, A Rai, S Pal… - New …, 2017 - Wiley Online Library
Withania somnifera produces pharmacologically important triterpenoid withanolides that are
derived via phytosterol pathway; however, their biosynthesis and regulation remain to be …

Role of withaferin A and its derivatives in the management of Alzheimer's disease: Recent trends and future perspectives

R Das, A Rauf, S Akhter, MN Islam, TB Emran, S Mitra… - Molecules, 2021 - mdpi.com
Globally, Alzheimer's disease (AD) is one of the most prevalent age-related
neurodegenerative disorders associated with cognitive decline and memory deficits due to …

A Decade of Molecular Understanding of Withanolide Biosynthesis and In vitro Studies in Withania somnifera (L.) Dunal: Prospects and Perspectives for Pathway …

N Dhar, S Razdan, S Rana, WW Bhat… - Frontiers in plant …, 2015 - frontiersin.org
Withania somnifera, a multipurpose medicinal plant is a rich reservoir of pharmaceutically
active triterpenoids that are steroidal lactones known as withanolides. Though the plant has …

Withania somnifera (L.) Dunal: A potential therapeutic adjuvant in cancer

A Saggam, G Tillu, S Dixit, P Chavan-Gautam… - Journal of …, 2020 - Elsevier
Ethnopharmacological relevance Withania somnifera (L.) Dunal (WS) is one of the
moststudied Rasayana botanicals used in Ayurveda practice for its immunomodulatory, anti …

Endophytes of Withania somnifera modulate in planta content and the site of withanolide biosynthesis

SS Pandey, S Singh, H Pandey, M Srivastava, T Ray… - Scientific reports, 2018 - nature.com
Tissue specific biosynthesis of secondary metabolites is a distinguished feature of medicinal
plants. Withania somnifera, source of pharmaceutically important withanolides …

Physiological and biochemical traits positively modulate tissue-specific withanolides and untargeted metabolites in Withania somnifera (L.) dunal under salinity stress

SA Thorat, M Srivaishnavi, A Kaniyassery… - Plant Physiology and …, 2023 - Elsevier
Abstract Withania somnifera (L.) Dunal (Ashwagandha) has been used in herbal medicines
worldwide and in the Indian traditional medicinal system for 3000 years. It is a member of the …

Advances in biochemistry and microbial production of squalene and its derivatives

GP Ghimire, HT Nguyen, N Koirala… - Journal of Microbiology …, 2016 - koreascience.kr
Squalene is a linear triterpene formed via the MVA or MEP biosynthetic pathway and is
widely distributed in bacteria, fungi, algae, plants, and animals. Metabolically, squalene is …

[HTML][HTML] The integration of metabolomics and next-generation sequencing data to elucidate the pathways of natural product metabolism in medicinal plants

F Scossa, M Benina, S Alseekh, Y Zhang… - Planta …, 2018 - thieme-connect.com
Plants have always been used as medicines since ancient times to treat diseases. The
knowledge around the active components of herbal preparations has remained …