Background The mechanisms underlying the non-antimicrobial immunomodulatory
properties of macrolides are not well understood. Objectives To systematically review the …

Azithromycin is a macrolide antibiotic which inhibits bacterial protein synthesis, quorum-
sensing and reduces the formation of biofilm. Accumulating effectively in cells, particularly …

Severe asthma in children is rare, accounting for only a small proportion of childhood
asthma. After addressing modifiable factors such as adherence to treatment, comorbidities …

Macrolides have diverse biological activities and an ability to modulate inflammation and
immunity in eukaryotes without affecting homeostatic immunity. These properties have led to …

Macrolides, as a class of natural or semisynthetic products, express their antibacterial
activity primarily by reversible binding to the bacterial 50S ribosomal subunits and by …

Background Macrolides have long been recognised to exert immunomodulary and anti-
inflammatory actions. They are able to suppress the “cytokine storm” of inflammation and to …

Azithromycin is a potent macrolide antibiotic with poorly understood antiinflammatory
properties. Long-term use of azithromycin in patients with chronic inflammatory lung …

Macrolide antibiotics administered in sub-antimicrobial doses improve pulmonary function
and decrease exacerbation frequency for persons with diffuse panbronchiolitis or cystic …

Macrolide antibiotics are well known for their antibacterial and anti-inflammatory properties.
This article provides an overview of the biological mechanisms through which macrolides …

Background COVID-19-associated acute respiratory distress syndrome (ARDS) is
associated with significant morbidity and high levels of mortality. This paper describes the …