[HTML][HTML] The role of mitochondria in amyotrophic lateral sclerosis
Mitochondria are unique organelles that are essential for a variety of cellular processes
including energy metabolism, calcium homeostasis, lipid biosynthesis, and apoptosis …
including energy metabolism, calcium homeostasis, lipid biosynthesis, and apoptosis …
[HTML][HTML] Autophagy dysregulation in ALS: when protein aggregates get out of hand
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that results from the
loss of upper and lower motor neurons. One of the key pathological hallmarks in diseased …
loss of upper and lower motor neurons. One of the key pathological hallmarks in diseased …
[HTML][HTML] TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response
Mutations in or dys-regulation of the TDP-43 gene have been associated with TDP-43
proteinopathy, a spectrum of neurodegenerative diseases including Frontotemporal Lobar …
proteinopathy, a spectrum of neurodegenerative diseases including Frontotemporal Lobar …
Functional significance of TDP-43 mutations in disease
E Buratti - Advances in genetics, 2015 - Elsevier
At present, there are very few therapeutic options for patients affected by amyotrophic lateral
sclerosis (ALS) and frontotemporal dementia (FTD). However, almost all patients affected by …
sclerosis (ALS) and frontotemporal dementia (FTD). However, almost all patients affected by …
Oxidative stress and mitochondrial damage in the pathogenesis of ALS: New perspectives
F Bozzo, A Mirra, MT Carrì - Neuroscience letters, 2017 - Elsevier
This review attempts to reconcile the present dual view of the mechanisms operating in
Amyotrophic Lateral Sclerosis (ALS). On one side, oxidative stress, mitochondrial damage …
Amyotrophic Lateral Sclerosis (ALS). On one side, oxidative stress, mitochondrial damage …
[HTML][HTML] Nuclear poly (ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis
L McGurk, J Mojsilovic-Petrovic, VM Van Deerlin… - Acta neuropathologica …, 2018 - Springer
Amyotrophic lateral sclerosis (ALS) is a devastating and fatal motor neuron disease.
Diagnosis typically occurs in the fifth decade of life and the disease progresses rapidly …
Diagnosis typically occurs in the fifth decade of life and the disease progresses rapidly …
[HTML][HTML] Dysregulation of RNA splicing in tauopathies
Pathological aggregation of RNA binding proteins (RBPs) is associated with dysregulation
of RNA splicing in PS19 P301S tau transgenic mice and in Alzheimer's disease brain …
of RNA splicing in PS19 P301S tau transgenic mice and in Alzheimer's disease brain …
[HTML][HTML] Nicotinamide as a foundation for treating neurodegenerative disease and metabolic disorders
K Maiese - Current neurovascular research, 2021 - ncbi.nlm.nih.gov
Neurodegenerative disorders impact more than one billion individuals worldwide and are
intimately tied to metabolic disease that can affect another nine hundred individuals …
intimately tied to metabolic disease that can affect another nine hundred individuals …
Pathways to mitochondrial dysfunction in ALS pathogenesis
MT Carrì, N D'Ambrosi, M Cozzolino - Biochemical and biophysical …, 2017 - Elsevier
Alterations in the structure and functions of mitochondria are a typical trait of Amyotrophic
Lateral Sclerosis, a neurodegenerative disease characterized by a prominent degeneration …
Lateral Sclerosis, a neurodegenerative disease characterized by a prominent degeneration …
[HTML][HTML] A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial–temporal regulation of histone arginine methylation in neurodevelopment
Abstract Background Oxidation Resistance 1 (OXR1) gene is a highly conserved gene of the
TLDc domain-containing family. OXR1 is involved in fundamental biological and cellular …
TLDc domain-containing family. OXR1 is involved in fundamental biological and cellular …