Osteoarthritis (OA) is one of the most debilitating diseases and is associated with a high
personal and socioeconomic burden. So far, there is no therapy available that effectively …

Bone degeneration associated with various diseases is increasing due to rapid aging,
sedentary lifestyles, and unhealthy diets. Living bone tissue has bioelectric properties critical …

The success of disease-modifying osteoarthritis drug (DMOAD) development is still elusive.
While there have been successes in preclinical and early clinical studies, phase 3 clinical …

Increased subchondral bone angiogenesis with blood vessels breaching the tidemark into
the avascular cartilage is a diagnostic feature of human osteoarthritis. However, the …

Osteoarthritis (OA), long considered a primary disorder of articular cartilage, is commonly
associated with subchondral bone sclerosis. However, the cellular mechanisms responsible …

With the aging world population, the prevalence of aging‐related disorders is on the rise.
Diseases such as Alzheimer's, type 2 diabetes mellitus (T2DM), Parkinson's …

To provide an extensive review on the associations between knee inflammation and altered
pain perception mechanisms in people with knee osteoarthritis (OA). MEDLINE, Web of …

Osteoarthritis (OA) is a leading cause of chronic pain and disability in older adults, which
most commonly affects the joints of the knee, hip, and hand. To date, there are no …

Molecular understanding of osteoarthritis (OA) has greatly increased over the past 15 years
through careful analysis of tissue samples, pre-clinical models and large-scale agnostic '∼ …

Osteoarthritis (OA) is a highly prevalent joint disease that is associated with pain, loss of
function, and high direct and indirect economic costs. The current therapeutic options are …