In this paper, we discuss the role of particle therapy—a novel radiation therapy (RT) that has
shown rapid progress and widespread use in recent years—in multidisciplinary treatment …

Proton therapy is increasingly being used as a radiation therapy modality. There is
uncertainty about the biological effectiveness of protons relative to photon therapies as it …

Simple Summary For the small subset of pancreatic ductal adenocarcinoma (PDAC) patients
with loss-of-function mutations to BRCA1/2 or PALB2, both first-line and maintenance …

BRCA1/2 pathogenic variants are widely known as major risk factors mainly for breast and
ovarian cancer, while their role in gastrointestinal (GI) malignancies such as colorectal …

Simple Summary Due to higher precision and consequent sparing of normal tissue,
pancreatic cancer patients might profit from proton beam radiotherapy, a treatment modality …

PARP was an enzyme found in the nucleus of eukaryotic cells that played a crucial role in
repairing damaged DNA. Recently, PARP inhibitors have demonstrated great potential in …

Gastric and oesophageal carcinoma remain major causes of worldwide mortality and
morbidity. Despite incredible progress in understanding tumour biology, few targeted …

Recently, it was established that ferroptosis, a type of iron-dependent regulated cell death,
plays a prominent role in radiotherapy-triggered cell death. Accordingly, ferroptosis inducers …

Radiotherapy (RT) is an effective treatment option for cancer; however, its efficacy remains
less than optimal in locally advanced cancer. Immune checkpoint inhibitor-based therapy …

Simple Summary Approximately 60% of patients with breast cancer require radiotherapy.
With significant advances in breast cancer outcomes, an increasing focus is being placed on …