There is a pressing need to reduce the high global disease burden of rheumatic heart
disease (RHD) and its harbinger, acute rheumatic fever (ARF). ARF is a classical example of …

Severe group A streptococcal disease including acute poststreptococcal glomerulonephritis
remains a cause of morbidity and mortality in developing countries and among …

Increasing evidence supports a central role of the immune system in acute post
streptococcal glomerulonephritis (APSGN), but the current view of how streptococcal biology …

Acute poststreptococcal GN (APSGN) is the prototype of immune complex GN and is
associated with manifestations of autoimmune reactivity that have been neglected as …

Background and aim: Patients with symptomatic primary hyperparathyroidism (pHT) have
increased cardiovascular morbidity and mortality. Endothelial nitric oxide synthase (eNOS) …

Acute glomerulonephritis that results from streptococcal infections is the best-studied
immune complex-mediated glomerulonephritis. Initially described in the convalescence of …

Coronary artery disease (CAD) is one of the frequent cardiovascular mortality causes in the
world. Common risk factors explain only about half the risk of CAD. The healthy familial …

Many infectious and noninfectious conditions can lead to the development of
glomerulonephritis (GN). The immunologic response of the kidney to an insult results in GN …

Nitric oxide (NO) is the major mediator in the regulation of vascular homeostasis. It is
synthesized by endothelium from arginine with the catalytic help of endothelial NO synthase …

Objective Endothelial nitric oxide synthase (eNOS) intron 4a/b polymorphism is associated
with plasma NO concentrations and coronary artery disease/hypertension in various …