Background Drug utilization studies are essential to facilitate rational drug use in the society.
Aim In this review, we provide an overview of drug utilization measures that can be used …

Background Probiotic supplementation has been used to alleviate abdominal pain in
children and adolescents with irritable bowel syndrome (IBS), but the evidence is not …

Objective After stratifying for age, sex and multimorbidity at baseline, our aim is to analyse
time trends in incident multimorbidity and polypharmacy in the 15-year clinical trajectories of …

Importance Pediatric palliative care treats patients with a wide variety of advanced illness
conditions, often with substantial levels of pain and other symptoms. Clinical and research …

BACKGROUND Research supports integrated pediatric behavioral health (BH), but
evidence gaps remain in ensuring equitable care for children of all ages. In response, an …

Importance Parents of children with severe neurological impairment (SNI) manage complex
medication regimens (CMRs) at home, and clinicians can help support parents and simplify …

Multimorbidity is of an increasing importance for the health of both children and adults but
research has hitherto focused on adult multimorbidity. Hence, public awareness, practice …

Introduction The risk of polypharmacy is on the rise in most industrialized countries,
threatening to burden their health systems. Although many definitions exist and numerous …

METHODS: This is a retrospective study of children ages 1 to 18 years using Medicaid from
10 states in 2014 grouped by the annual number of CMs (0, 1, 2–4, 5–9, and≥ 10 …

In pediatric individuals, polypharmacy would increase the prevalence of adverse drug
reactions (ADRs). However, there is no report on the ADR increase adjusted for the …