The essential physiological role of platelets in wound healing and tissue repair builds the
rationale for the use of human platelet derivatives in regenerative medicine. Abundant …

Platelets are small anucleated blood cells primarily known for their vital hemostatic role.
Allogeneic platelet concentrates (PCs) collected from healthy donors are an essential …

The use of fetal bovine serum (FBS) as a cell culture supplement is discouraged by
regulatory authorities to limit the risk of zoonoses and xenogeneic immune reactions in the …

Despite the popularity of platelet-rich plasma (PRP) and platelet lysate (PL) in orthopaedic
practice, the mechanism of action and the effectiveness of these therapeutic tools are still …

Human platelet lysate (HPL), rich in growth factors, is an efficient alternative supplement to
fetal bovine serum (FBS) for ex vivo propagation of stromal cell-based medicinal products …

Abstract Background Glucocorticoids (GCs) overuse is associated with decreased bone
mass and osseous vasculature destruction, leading to severe osteoporosis. Platelet lysates …

The application of cell-based therapeutics requires development of refined and scalable
culture processes. Stirred tank bioreactors facilitate growth of human mesenchymal stromal …

Most clinical applications of human multipotent mesenchymal stromal cells (MSCs) for cell
therapy, tissue engineering, regenerative medicine, and treatment of immune and …

Numerous cell-based therapeutics are currently being tested in clinical trials. Human platelet
lysate (HPL) is a valuable alternative to fetal bovine serum as a cell culture medium …

Umbilical cord (UC) is a rich source of rapidly proliferating mesenchymal stem cells (MSCs)
that are easily cultured on a large-scale. Clinical applications of UC–MSCs include graft …