The plant viruses and molecular farming: how beneficial they might be for human and animal health?

G Zahmanova, AA Aljabali, K Takova, V Toneva… - International Journal of …, 2023 - mdpi.com
Plant viruses have traditionally been studied as pathogens in the context of understanding
the molecular and cellular mechanisms of a particular disease affecting crops. In recent …

The re-emergence of hepatitis E virus in Europe and vaccine development

G Zahmanova, K Takova, V Tonova, T Koynarski… - Viruses, 2023 - mdpi.com
Hepatitis E virus (HEV) is one of the leading causes of acute viral hepatitis. Transmission of
HEV mainly occurs via the fecal-oral route (ingesting contaminated water or food) or by …

Combating human viral diseases: will plant-based vaccines be the answer?

S Venkataraman, K Hefferon, A Makhzoum… - Vaccines, 2021 - mdpi.com
Molecular pharming or the technology of application of plants and plant cell culture to
manufacture high-value recombinant proteins has progressed a long way over the last three …

[HTML][HTML] Plant-Produced Chimeric Hepatitis E Virus-like Particles as Carriers for Antigen Presentation

ES Mardanova, EA Vasyagin, KG Kotova… - Viruses, 2024 - mdpi.com
A wide range of virus-like particles (VLPs) is extensively employed as carriers to display
various antigens for vaccine development to fight against different infections. The plant …

[HTML][HTML] Virus-like particles produced in plants: A promising platform for recombinant vaccine development

ES Mardanova, EA Vasyagin, NV Ravin - Plants, 2024 - pmc.ncbi.nlm.nih.gov
The capsid proteins of many viruses are capable of spontaneous self-assembly into virus-
like particles (VLPs), which do not contain the viral genome and are therefore not infectious …

Green biologics: harnessing the power of plants to produce pharmaceuticals

G Zahmanova, AAA Aljabali, K Takova… - International Journal of …, 2023 - mdpi.com
Plants are increasingly used for the production of high-quality biological molecules for use
as pharmaceuticals and biomaterials in industry. Plants have proved that they can produce …

High-yield production of chimeric hepatitis E virus-like particles bearing the M2e influenza epitope and receptor binding domain of SARS-CoV-2 in plants using viral …

ES Mardanova, RY Kotlyarov… - International Journal of …, 2022 - mdpi.com
Capsid protein of Hepatitis E virus (HEV) is capable of self-assembly into virus-like particles
(VLPs) when expressed in Nicotiana benthamiana plants. Such VLPs could be used as …

Increasing hepatitis E virus seroprevalence in domestic pigs and wild boar in Bulgaria

K Takova, T Koynarski, I Minkov, Z Ivanova, V Toneva… - Animals, 2020 - mdpi.com
Simple Summary Hepatitis E virus (HEV) is a lesser-known hepatitis virus, but its worldwide
spread is undisputed and has increased in recent years. The zoonotic spread of HEV …

Efficient Production of Chimeric Hepatitis B Virus-Like Particles Bearing an Epitope of Hepatitis E Virus Capsid by Transient Expression in Nicotiana benthamiana

G Zahmanova, M Mazalovska, K Takova, V Toneva… - Life, 2021 - mdpi.com
The core antigen of hepatitis B virus (HBcAg) is capable of self-assembly into virus-like
particles (VLPs) when expressed in a number of heterologous systems. Such VLPs are …

Plant-derived recombinant vaccines against zoonotic viruses

G Zahmanova, K Takova, R Valkova, V Toneva… - Life, 2022 - mdpi.com
Emerging and re-emerging zoonotic diseases cause serious illness with billions of cases,
and millions of deaths. The most effective way to restrict the spread of zoonotic viruses …